dc.contributor.author | O'NEILL, LUKE | en |
dc.contributor.author | SHEEDY, FREDERICK | en |
dc.date.accessioned | 2011-06-15T10:10:53Z | |
dc.date.available | 2011-06-15T10:10:53Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA., Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6, Journal of Biological Chemistry, 286, 29, 2011, 25531-9 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/56904 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Toll-like receptors (TLRs) modulate the expression of multiple microRNAs (miRNAs). Here we report the down-regulation of miR-107 by TLR4 in multiple cell types. The miR-107 sequence occurs in an intron within the sequence encoding the gene for Pantothenate kinase-1? (PanK1?), which is regulated by the transcription factor PPAR-?. PanK1? is also decreased in response to lipopolysaccharide (LPS). The effect on both miR-107 and PanK1? is consistent with a decrease in PPAR-? expression. We have found that the putative miR-107 target cyclin-dependent-kinase 6 (CDK6) expression is increased by TLR4 as a result of the decrease in miR-107. This effect is required for increased adhesion of macrophages in response to LPS, and CDK6- deficient mice are resistant to the lethal effect of LPS. We have therefore identified a mechanism for LPS signaling which involves a decrease in miR-107 leading to an increase in CDK6. | en |
dc.format.extent | 25531-9 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Journal of Biological Chemistry | en |
dc.relation.ispartofseries | 286 | en |
dc.relation.ispartofseries | 29 | en |
dc.rights | Y | en |
dc.subject | Oncology | en |
dc.subject | Genetics | en |
dc.subject | Cellular immune response | en |
dc.subject | Toll-like receptors (TLR) | en |
dc.title | Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6 | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/laoneill | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/fsheedy | en |
dc.identifier.rssinternalid | 73665 | en |
dc.identifier.doi | http://dx.doi.org/10.1074/jbc.M111.256206 | en |
dc.subject.TCDTheme | Cancer | en |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.rssuri | http://www.jbc.org/cgi/doi/10.1074/jbc.M111.256206 | en |