dc.contributor.author | MEEGAN, MARY | en |
dc.contributor.author | MCCABE, THOMAS | en |
dc.date.accessioned | 2014-02-27T15:06:13Z | |
dc.date.available | 2014-02-27T15:06:13Z | |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | McNamara, Y. M. Bright, S. A. Byrne, A. J. Cloonan, Suzanne M. McCabe, T. Williams, D. C. Meegan, M. J., Synthesis and antiproliferative action of a novel series of maprotiline analogues, European Journal of Medicinal Chemistry, 2014 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/68169 | |
dc.description | PUBLISHED | en |
dc.description.abstract | The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative agent against Burkitt?s lymphoma (BL) cell lines is reported. A series of 9,10-dihydro-9,10-ethanoanthracenes was synthesised with modifications to the bridge of the dihydroethanoanthracene structure and with alterations to the basic side chain. A number of compounds were found to reduce cell viability to a greater extent than maprotiline in BL cell lines. In addition a related series of novel 9- substituted anthracene compounds was investigated as intermediates in the synthesis of 9,10-dihydro-9,10-ethanoanthracenes. These compounds proved the most active from the screen and were found to exert a potent caspase-dependant apoptotic effect in the BL cell lines, while having minimal effect on the viability of peripheral blood mononuclear Cells (PBMCs). Compounds also displayed activity in multi-drug resistant (MDR) cells. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | European Journal of Medicinal Chemistry | en |
dc.rights | Y | en |
dc.subject | Burkitt?s lymphoma | en |
dc.title | Synthesis and antiproliferative action of a novel series of maprotiline analogues | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mmeegan | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/tmccabe | en |
dc.identifier.rssinternalid | 92221 | en |
dc.rights.ecaccessrights | OpenAccess | |