dc.contributor.author | MARTIN, SEAMUS | en |
dc.date.accessioned | 2014-04-10T14:39:49Z | |
dc.date.available | 2014-04-10T14:39:49Z | |
dc.date.issued | 2009 | en |
dc.date.submitted | 2009 | en |
dc.identifier.citation | Autret A, Martin SJ, Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis., Molecular cell, 36, 3, 2009, 355-63 | en |
dc.identifier.issn | 1097-2765 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/68461 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated cytochrome c release, while others suggest that these functions are separable. Here we review this emerging area and argue for a role for the Bcl-2 family as novel regulators of mitochondrial morphogenesis. | en |
dc.format.extent | 355-63 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Molecular cell | en |
dc.relation.ispartofseries | 36 | en |
dc.relation.ispartofseries | 3 | en |
dc.rights | Y | en |
dc.subject | mitochondrial morphogenesis | en |
dc.title | Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/martinsj | en |
dc.identifier.rssinternalid | 64489 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.molcel.2009.10.011 | en |
dc.rights.ecaccessrights | OpenAccess | |