dc.contributor.author | O'FARRELLY, CLIONA | en |
dc.date.accessioned | 2014-08-06T13:49:58Z | |
dc.date.available | 2014-08-06T13:49:58Z | |
dc.date.issued | 2013 | en |
dc.date.submitted | 2013 | en |
dc.identifier.citation | Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, 7, 2013, e69090 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/70698 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Bioinformatic analysis identified highly conserved 3’UTR miR-19a target sequences in several JAK-STAT associated genes, including SOCS1, SOCS3, SOCS5 and Cullin (Cul) 5. Functional studies revealed that miR-19a significantly decreased SOCS3 mRNA and protein, while a miR-19a antagomir specifically reversed its inhibitory effect. Furthermore, miR-19a-mediated reduction of SOCS3 enhanced IFN-α and interleukin (IL)-6 signal transduction through STAT3. These results reveal a novel mechanism by which miR-19a may augment JAK-STAT signal transduction via control of SOCS3 expression and are fundamental to the understanding of inflammatory regulation. | en |
dc.format.extent | e69090 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | PloS one | en |
dc.relation.ispartofseries | 8 | en |
dc.relation.ispartofseries | 7 | en |
dc.rights | Y | en |
dc.subject | 3’UTR | en |
dc.subject | Cytokines | en |
dc.subject | DNA-binding proteins | en |
dc.subject | Gene expression | en |
dc.subject | Gene targeting | en |
dc.subject | MicroRNAs | en |
dc.subject | STAT proteins | en |
dc.title | miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ofarrecl | en |
dc.identifier.rssinternalid | 93962 | en |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0069090 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |