Browsing Trinity College Dublin, the University of Dublin: Theses & Dissertations by Sponsor "Health Research Board (HRB)"
Now showing items 21-40 of 48
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HUMAN HEPATIC NATURAL KILLER CELLS IN HEALTH AND MALIGNANCY
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The adult human liver is described as an immunologically tolerogenic organ, maintaining a homeostatic environment while bombarded by dietary antigens, microbial products and metabolic by-products. The liver is also a site ... -
The Impact of Performing a Network Meta-Analysis with Imperfect Evidence
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Statistics, 2019)Network meta-analysis (NMA) is an important aspect of evidence synthesis in a clinical setting, as it allows us to compare treatments which may not have been analysed in the same trial. In an ideal scenario we would have ... -
Investigating a role for TLR signalling and complement deposition in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of progressive vision loss in the developed world. AMD is a multifactorial disease with both genetic and environmental risk ... -
Investigating the Effects of FTY720 on Spatial Memory and Neuroinflammation in a Rodent Model of Alzheimer's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder characterized by memory loss and cognitive decline, with loss of global functioning over time eventually leading to death. At the molecular ... -
Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Introduction: Pancreatic adenocarcinoma (PDAC), while often described a rare or neglected cancer, is the fourth cause of cancer-related mortality in the US and Europe. Unintentional weight loss is a prominent feature of ... -
Investigating the Neural Correlates of Cervical Dystonia and Temporal Discrimination using Neuroimaging based Computational Modelling and Multimodal Pattern Recognition
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2020)Movement disorders, such as Parkinson s disease and Dystonia, have traditionally been considered as disorders of impaired motor control resulting predominantly from dysfunction of the Basal Ganglia. However, there has been ... -
Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)The human liver is an immunologically complex organ populated with distinct resident immune cells including liver-resident CD56bright NK (lrNK) cells which have a distinct CD69+CXCR6+T-betloEomeshi phenotype. These ... -
Investigating the Role of Altered Energy Metabolism in the Therapeutic Response of Rectal Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Colorectal cancer (CRC) is the 3rd most commonly diagnosed cancer world-wide, accounting for an estimated 10% of all cancers diagnosed annually globally. One in three CRCs occur in the rectum. The standard of care for ... -
An investigation of the effect of maternal depression during pregnancy on maternal and infant hypothalamic-pituitary-adrenal axes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Background: Pregnancy is a period of increased vulnerability for developing depression. Several maternal physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis undergo changes during pregnancy. ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
Measuring physical function in Amyotrophic Lateral Sclerosis: Novel solutions to an old problem
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Sensitive, objective outcome measures are essential for tracking clinical severity in neurodegenerative conditions such as Amyotrophic Lateral Sclerosis or Parkinson’s Disease. The current ‘gold standard’ multi-item rating ... -
Mindfulness meditation and the clinically modified Buddhist psychological model in psoriasis
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2019)The literature on psoriasis highlights that having this chronic incurable condition can result in patients experiencing a heavy psychosocial burden, which can result in higher levels of anxiety, depression, and poorer ... -
Multidisciplinary Rehabilitation in Oesophago-gastric Cancer Surviorship
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2018)As survival rates for oesophageal and gastric cancer slowly improve, there has been an emergence of a unique cohort of cancer survivors who present with multifaceted nutritional and physical needs which are amenable to ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
The OPTIMAL study: A randomized controlled trial and process evaluation of an occupational therapy led self-management support programme for people with multimorbidity in primary care
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2019)Title: The OPTIMAL study: A randomized controlled trial and process evaluation of an occupational therapy led self-management support programme for people with multimorbidity in primary care PhD candidate: Lynn O ... -
Oral Health Status of community dwelling older adults and its relationship with general health conditions
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2020)Background The ageing population is one of the great challenges that will confront health services in developed countries in the coming years. It is estimated that by 2050, the number of adults aged 60 years and older ... -
Parent-Child Interaction and the Developmental Profile of Children following Neonatal Encephalopathy
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Neonatal Encephalopathy (NE) is a clinical condition characterised by disturbed neurological functioning in newborn infants and is associated with unfavourable outcomes including developmental delay. It is estimated that ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
Postpartum sexual health in nulliparous women in Ireland: a mixed methods study
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2019)Background: Prevalence rates of postpartum sexual health issues and associated factors vary greatly in the published literature. There is a focus on biophysical measures of postpartum sexual health and a lack of women's ...