Regulatory T cell induction and function
Citation:
Kevin Walsh, 'Regulatory T cell induction and function', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009, pp 300Download Item:
Abstract:
The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production from DC and thereby induce Th1 cells. However, recent studies have suggested that TLR agonists may simultaneously induce IL-10 producing Treg (Tr1) cells. In the present study, this property was explored and exploited in order to develop methods of selectively inducing Tr1 cells, in the development of potential therapies for auto-immune diseases mediated by Th1 and IL-17 producing T (Th17) cells.
Author: Walsh, Kevin
Advisor:
Mills, KingstonQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Full text availableKeywords:
Biochemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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