Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium
Citation:
Aoife Colgan, 'Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2015, pp 323Download Item:
Abstract:
Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important foodborne pathogen that causes self-limiting gastroenteritis, or more serious systemic infections in susceptible hosts. S. Typhimurium can infect a wide host range and encounters a series of stressful conditions within various host environments. S. Typhimurium expresses a Type Three Secretion System (TTSS) encoded on a pathogenicity island (SPI1), to mediate invasion of the host intestinal epithelium. Once internalised, S. Typhimurium survives and replicates within the Salmonella containing vacuole (SCV). S. Typhimurium expresses a second TTSS, encoded on a second pathogenicity island (SPI2), to survive the harsh intracellular environment and establish systemic infection.
Author: Colgan, Aoife
Advisor:
Hinton, JayQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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