dc.contributor.author | WELLMER, FRANK | en |
dc.date.accessioned | 2017-03-09T09:37:08Z | |
dc.date.available | 2017-03-09T09:37:08Z | |
dc.date.issued | 2016 | en |
dc.date.submitted | 2016 | en |
dc.identifier.citation | de Marchi, R., Sorel, M., Mooney, B., Fudal, I., Goslin, K., Kwasniewska, K., Ryan, P.T., Pfalz, M., Kroymann, J, Pollmann, S., Feechan, A., Wellmer, F., Rivas, S., and Graciet, E., The N-end rule pathway regulates pathogen responses in plants., Scientific Reports, 6, 2016, 26020 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/79651 | |
dc.description | PUBLISHED | en |
dc.description.abstract | To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination of the plant immune response is known to require the activity of the ubiquitin/proteasome system, which controls the stability of proteins in eukaryotes. Here, we demonstrate that the N-end rule pathway, a subset of the ubiquitin/proteasome system, regulates the defense against a wide range of bacterial and fungal pathogens in the model plant Arabidopsis thaliana. We show that this pathway positively regulates the biosynthesis of plant-defense metabolites such as glucosinolates, as well as the biosynthesis and response to the phytohormone jasmonic acid, which plays a key role in plant immunity. Our results also suggest that the arginylation branch of the N-end rule pathway regulates the timing and amplitude of the defense program against the model pathogen Pseudomonas syringae AvrRpm1. | en |
dc.description.sponsorship | We thank Liina Rae and Brian Fagan for technical assistance, Fiona Doohan for helpful discussions and access to growth facilities, and Gary Loake for sharing the Erysiphe cruciferarum strain. We are grateful to Fabienne Vailleau, Thomas Badet and Pascal Le Pêcheur for help with Ralstonia, Sclerotinia and Botrytis inoculations, respectively. This study was supported by grants from Science Foundation Ireland to EG (13/IA/1870) and FW (10/IN.1/B2970). BM is supported by the Virtual Irish Centre for Crop Improvement, funded by the Department of Agriculture, Food and the Marine (project 14/S/819). Work at the LIPM is supported by the French Laboratory of Excellence project “TULIP” (ANR-10-LABX-41; ANR-11-IDEX-0002-02). We also wish to acknowledge funding by Science Foundation Ireland (SFI/07/RFP/GEN/F571/ECO7) for the quantitative PCR instrumentation. | en |
dc.format.extent | 26020 | en |
dc.relation.ispartofseries | Scientific Reports | en |
dc.relation.ispartofseries | 6 | en |
dc.rights | Y | en |
dc.subject | immune responses | en |
dc.subject.lcsh | immune responses | en |
dc.title | The N-end rule pathway regulates pathogen responses in plants. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/wellmerf | en |
dc.identifier.rssinternalid | 114917 | en |
dc.identifier.doi | http://dx.doi.org/10.1038/srep26020 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTag | Cell signalling, proliferation & differentiation | en |
dc.subject.TCDTag | Genomes, Genomics | en |
dc.subject.TCDTag | Molecular Biology | en |
dc.identifier.orcid_id | 0000-0002-2095-0981 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | SFI/07/RFP/GEN/F571/ECO7 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 13/IA/1870 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 10/IN.1/B2970 | en |