Construction and characterisation of a Semliki Forest virus vector based rubella prototype vaccine
Citation:
Sara Jane Callagy, 'Construction and characterisation of a Semliki Forest virus vector based rubella prototype vaccine', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2007, pp 239Download Item:
Abstract:
Alphavirus vaccines such as those based on the Semliki Forest virus (SFV) replicon
have been widely studied as candidate vaccines. Following intramuscular injection,
dispersal of the RNA occurs to the local lymph node only, persisting only for 7 days.
Recombinant SFV (rSFV) particles are suicidal and undergo only one round of
multiplication, killing the cells by apoptosis induction. Replication of RNA is entirely
cytoplasmic thus there is no possibility of insertional mutagenesis. Vaccination against
rubella is contra-indicated in pregnant women or those considering pregnancy because of
the risk of infection of the developing foetus, and such women therefore remain at risk of
infection with the wild-type virus and consequent congenital rubella syndrome in the infant
after birth.
Author: Callagy, Sara Jane
Advisor:
Atkins, GregoryQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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