Molecular characterisation of the Salmonella-specific protein PagN
Citation:
Matthew A. Lambert, 'Molecular characterisation of the Salmonella-specific protein PagN', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2007, pp 262Abstract:
Salmonella infect a broad spectrum of animals resulting in host responses ranging from
severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as
fever or self-limiting gastroenteritis. Illness due to Salmonella infection is a serious problem
in both developed and developing countries, affecting both humans and animals alike.
Central to the ability of Salmonella to cause disease is its capacity to penetrate the intestinal
mucosa. Once internalised massive fluid secretion takes place resulting in diarrhoea. The
bacteria can cross the basolateral membrane and disseminate around the host body leading to
systemic infection. Much work has been carried out investigating the pathogenesis of
Salmonella and elucidating the steps involved in disease. Many of the virulence determinants
have been identified and characterised.
Author: Lambert, Matthew A.
Advisor:
Smith, StephenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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thesisAvailability:
Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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