Enantioselective receptors via one-bead one-compound combinatorial libraries
Citation:
Patricia Amy Kelly, 'Enantioselective receptors via one-bead one-compound combinatorial libraries', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2003, pp 180Abstract:
Chapter 1 describes the overall aim of this project, which is to extend the range of steroid-based receptors synthesised by the Davis group, using the combinatorial chemistry approach instead of traditional design and synthesis methods. The
importance of an efficient method of screening combinatorial libraries for "hits", and the application of such a technique to the discovery of steroid-based enantioselective receptors, are described in Chapter 2. The target assay, wherein a solid-phase bound
combinatorial library o f receptors is exposed to racemic guest, of which each enantiomer is differentially colour-tagged, is also described. Chapter 3 describes a method whereby a semi-quantitative estimate of the enantioselectivity of individual bead-bound receptors may be obtained, by use of isotopically differentiated enantiomers.
Author: Kelly, Patricia Amy
Advisor:
Corish, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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thesisAvailability:
Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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