Biomechanical origins of osteoporosis
Citation:
Laoise Maria McNamara, 'Biomechanical origins of osteoporosis', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004, pp 195Download Item:
Abstract:
The contention of this thesis is that a pathological change in bone tissue material properties during osteoporosis ahers the mechanical stimuli to bone remodelling cells
and drives them to adapt the trabecular architecture resulting in a reduction in bone strength. To argue the case for this thesis, three separate but inter-related hypotheses
with respect to the regulatory mechanisms governing bone remodelling are tested. These hypotheses are (1) A pathological change in the material properties of bone
tissue occurs during osteoporosis, (2) Bone remodelling is regulated by a combination of strain and damage, and (3) Suppressing bone turnover in drug treated bone results
in weaker bone tissue than that of normal and osteoporotic bone.
Author: McNamara, Laoise Maria
Advisor:
Prendergast, PatrickQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing EngineeringNote:
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