To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps
Citation:
Boeltz, S., Amini, P., Anders, H.-J., Andrade, F., Bilyy, R., Chatfield, S., Cichon, I., Clancy, D.M,, Desai, J., Dumych, T., Dwivedi, N., Gordon, R.A., Hahn, J., Hidalgo, A., Hoffmann, M.H., Kaplan, M.J., Knight J.S., Kolaczkowska, E., Kubes, P., Leppkes, M., Manfredi, A.A., Martin, S.J., Maueroder, C., Maugeri, N., Mitroulis, I., Munoz, L.E., Nakazawa, D., Neeli, I., Nizet, V., Pieterse, E., Radic, M.Z., Reinwald, C., Ritis, K., Rovere-Querini, P., Santocki, M., Schauer, C., Schett, G., Shlomchik, M.J., Simon, H.-U., Skendros, P., Stojkov, D., Vandenabeele, P., Berghe, T.V., van der Vlag, J., Vitkov, L., von Kockritz-Blickwede, M., Yousefi, S., Zarbock, A., Herrmann, M. To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps, Cell Death and Differentiation, 2019, 26, 3, 395 - 408Download Item:
Abstract:
Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics andphysiological functions of NETs have been uncovered. Nowadays, thefield continues to expand and novel mechanisms thatorchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge.The abundance of available data has also led to some confusion in the NET research community due to contradictory resultsand divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from otherforms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state ofthe science in NET-related research and elaborate on open questions and areas of dispute
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http://people.tcd.ie/martinsjDescription:
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Author: Martin, Seamus
Publisher:
Springer NatureType of material:
Journal ArticleCollections
Series/Report no:
Cell Death and Differentiation;26;
3;
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Full text availableKeywords:
Neutrophils, Histones, Extracellular trap, Cell death and immune response, Immune cell death, Inflammation, ProteolysisDOI:
http://dx.doi.org/10.1038/s41418-018-0261-xMetadata
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