Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
Citation:
Jackie N. Dolan, 'Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2013, pp 235Download Item:
Abstract:
The functional brain is critically dependent on a highly specific and perfectly timed
gene-expression programme that underlies neuronal connectivity. Each step of
this process, which includes cell migration, axon guidance, target selection and
synaptogenesis, requires a vast number of molecules. While many genes with
roles in these processes have been identified to date, the astonishing complexity
and specificity of neural connections suggests that further molecules yetunidentified
are involved. Leucine-rich repeat (LRR)-containing proteins are
known to play crucial roles in the developing central nervous system. This led to
the hypothesis that additional genes from this class of proteins could provide the
necessary specificity of cellular interactions involved in neural connectivity.
Author: Dolan, Jackie N.
Advisor:
Mitchell, KevinQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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