Interferon lambda, dendritic cells and Hepatitis C virus infection
Citation:
Aoife Kelly, 'Interferon lambda, dendritic cells and Hepatitis C virus infection', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013, pp 224Download Item:
Abstract:
It is estimated that ~3% of the world's population is infected with Hepatitis C
virus (HCV), a hepatotropic virus which can lead to liver fibrosis, cirrhosis and
hepatocellular carcinoma. Of those infected, ~20% clear the virus naturally
whereas the majority develop chronic infection. Response to the current therapy,
the important antiviral cytokine interferon alpha (IFN-a), also varies with
response rates of less than 50% in some cohorts. The inter-individual variation in
clinical outcome to HCV infection highlights the contribution of genetic variation to
the host antiviral response to infection.
Author: Kelly, Aoife
Advisor:
O'Farrelly, ClionaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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