| dc.contributor.author | Mcgouran, Joanna | en |
| dc.contributor.author | Senge, Mathias | en |
| dc.contributor.author | Scanlan, Eoin | en |
| dc.date.accessioned | 2020-01-09T15:29:28Z | |
| dc.date.available | 2020-01-09T15:29:28Z | |
| dc.date.issued | 2019 | en |
| dc.date.submitted | 2019 | en |
| dc.identifier.citation | Doherty W., Durr E.-M., Baddock H.T., Lee S.Y., McHugh P.J., Brown T., Senge M.O., Scanlan E.M., McGouran J.F., A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A, Organic and Biomolecular Chemistry, 17, 35, 2019, 8094 - 8105 | en |
| dc.identifier.issn | 14770520 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01133A#!divAbstract | |
| dc.identifier.uri | http://hdl.handle.net/2262/91282 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors. | en |
| dc.format.extent | 8094 | en |
| dc.format.extent | 8105 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Organic and Biomolecular Chemistry | en |
| dc.relation.ispartofseries | 17 | en |
| dc.relation.ispartofseries | 35 | en |
| dc.rights | Y | en |
| dc.subject | DNA repair | en |
| dc.subject | Nuclease SNM1A | en |
| dc.subject | Cancer treatment | en |
| dc.title | A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/jmcgoura | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/scanlae | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | en |
| dc.identifier.rssinternalid | 209646 | en |
| dc.identifier.doi | http://dx.doi.org/10.1039/c9ob01133a | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.orcid_id | 0000-0002-9349-2141 | en |
