| dc.contributor.author | Mcgouran, Joanna | en |
| dc.date.accessioned | 2020-01-09T15:49:19Z | |
| dc.date.available | 2020-01-09T15:49:19Z | |
| dc.date.issued | 2019 | en |
| dc.date.submitted | 2019 | en |
| dc.identifier.citation | Thomas A.M., Brolih S., McGouran J.F., El-Sagheer A.H., Ptchelkine D., Jones M., McDonald N.Q., McHugh P.J., Brown T., Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors, Chemical Communications, 55, 78, 2019, 11671 - 11674 | en |
| dc.identifier.issn | 1364548X 13597345 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC05476F#!divAbstract | |
| dc.identifier.uri | http://hdl.handle.net/2262/91283 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | We report the design and optimisation of novel oligonucleotide
substrates for a sensitive fluorescence assay for high-throughput
screening and functional studies of the DNA repair enzyme, XPFERCC1,
with a view to accelerating inhibitor and drug discovery. | en |
| dc.format.extent | 11671 | en |
| dc.format.extent | 11674 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Chemical Communications | en |
| dc.relation.ispartofseries | 55 | en |
| dc.relation.ispartofseries | 78 | en |
| dc.rights | Y | en |
| dc.subject | DNA repair | en |
| dc.subject | Chemotherapy | en |
| dc.subject | XPF-ERCC1 | en |
| dc.title | Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/jmcgoura | en |
| dc.identifier.rssinternalid | 209649 | en |
| dc.identifier.doi | http://dx.doi.org/10.1039/c9cc05476f | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.orcid_id | 0000-0002-9349-2141 | en |
