Hydrogels: Soft matters in photomedicine
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2019Access:
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Khuruna, B., Gierlich, P., Meindl, A., Gomes-da-Silva, L.C. & Senge, M.O., Hydrogels: Soft matters in photomedicine, 2019, Photochemical and Photobiological Sciences, 18, 11Download Item:
Abstract:
Photodynamic therapy (PDT), a shining beacon in the realm of photomedicine, is a non‐invasive technique that utilizes dyebased
photosensitizers (PSs) in conjunction with light and oxygen to produce reactive oxygen species to combat malignant
tissue and infectious microorganisms. Yet, for PDT to become a common, routine therapy, it is still necessary to overcome
limitations such as photosensitizer solubility, long‐term side effects (e. g., photosensitivity) and to develop safe,
biocompatible and target‐specific formulations. Polymer based drug delivery platforms are an effective strategy for the
delivery of PSs for PDT applications. Among them, hydrogels, 3D polymer scaffolds with the ability to swell in aqueous media
have been deeply investigated. Particularly, hydrogels‐based formulations present a real potential to fulfill all requirements
of an ideal PDT platform by overcoming the solubility issues, while improving the selectivity and targeting drawbacks of the
PSs alone. In this perspective, we summarize the use of hydrogels as carrier systems of PSs to enhance the effectiveness of
PDT against infections and cancer. Their potential in environmental and biomedical applications, such as tissue engineering
photoremediation and photochemistry, is also discussed
URI:
https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00221A#!divAbstracthttp://hdl.handle.net/2262/91456
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Science Foundation Ireland
IvP 13/IA/1894
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http://people.tcd.ie/sengemType of material:
Journal ArticleURI:
https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00221A#!divAbstracthttp://hdl.handle.net/2262/91456
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Photochemical and Photobiological Sciences;18;
11;
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http://dx.doi.org/10.1039/c9pp00221aMetadata
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