dc.contributor.author | Mc Lysaght, Aoife | |
dc.date.accessioned | 2020-03-21T06:49:38Z | |
dc.date.available | 2020-03-21T06:49:38Z | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020 | en |
dc.identifier.citation | Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman II, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O’Donnell, Trey Ideker & Anne-Ruxandra Carvunis, 'De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences', 2020, Nature Communications;, 11;, 781; | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/91844 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Recent evidence demonstrates that novel protein-coding genes can arise de novo from non- genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable polypeptides to natural selection. Here, we systematically characterize how these de novo emerging coding sequences impact fitness in budding yeast. Disruption of emerging sequences is generally inconsequential for fitness in the laboratory and in natural populations. Overexpression of emerging sequences, however, is enriched in adaptive fitness effects compared to over- expression of established genes. We find that adaptive emerging sequences tend to encode putative transmembrane domains, and that thymine-rich intergenic regions harbor a wide- spread potential to produce transmembrane domains. These findings, together with in-depth examination of the de novo emerging YBR196C-A locus, suggest a novel evolutionary model whereby adaptive transmembrane polypeptides emerge de novo from thymine-rich non- genic regions and subsequently accumulate changes molded by natural selection. | en |
dc.description.sponsorship | This work was supported by: funds provided by the Searle Scholars Program to A.-R.C.; the National Institute of General Medical Sciences of the National Institutes of Health grants R00GM108865 and DP2GM137422 (awarded to A.-R.C.), P41GM103504 (awarded to T.I.), 5R01GM097084 (awarded to C.J.C.) and F32GM129929 (awarded to B.V.O.); the National Institute of Environmental Health Sciences of the National Institutes of Health grant R01ES014811 (awarded to T.I.); the National Science Foundation MCB CAREER grant 1902859 (awarded to A.F.O.); funding from the European Research Council grant agreements 309834 and 771419 (awarded to AMcL). | en |
dc.format.extent | 1-18 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Nature Communications; | |
dc.relation.ispartofseries | 11; | |
dc.relation.ispartofseries | 781; | |
dc.relation.uri | https://github.com/annerux/AdaptiveTMproto-genes | en |
dc.relation.uri | https://github.com/annerux/AdaptiveTMproto-genes. | en |
dc.relation.uri | https://github.com/bbhsu/protogene-analysis | en |
dc.relation.uri | https://github.com/oacar/synal | en |
dc.rights | Y | en |
dc.subject | adaptive membrane proteins | en |
dc.subject | protein-coding genes | en |
dc.title | De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences | en |
dc.type | Journal Article | en |
dc.relation.references | References | en |
dc.relation.references | References | en |
dc.relation.references | References | en |
dc.relation.references | References | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mclysaga | |
dc.identifier.rssinternalid | 215021 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-020-14500-z | |
dc.relation.ecprojectid | info:eu-repo/grantAgreement/EC/FP7/309834 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Genes & Society | en |
dc.identifier.orcid_id | 0000-0003-2552-6220 | |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.sponsorGrantNumber | 309834 | en |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.sponsorGrantNumber | 771419 | en |