dc.contributor.author | Senge, Mathias | |
dc.date.accessioned | 2021-02-25T15:44:38Z | |
dc.date.available | 2021-02-25T15:44:38Z | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020 | en |
dc.identifier.citation | Mathias Senge, 'Exploring the relationship between structure and activity in BODIPYs designed for antimicrobial phototherapy', 2020, Organic and Biomolecular Chemistry;, 18;, 13; | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/95392 | |
dc.description.abstract | A synthetic strategy to BODIPY dyes is presented giving access to a range of new compounds relevant in the context of antimicrobial photodynamic therapy (aPDT). BODIPYs with the 8-(4-fluoro-3-nitrophenyl) and the 8-pentafluorophenyl substituents were used for the synthesis of new mono- and dibrominated BODIPYs. The para-fluorine atoms in these electron-withdrawing groups facilitate functional modification via nucleophilic aromatic substitution (SNAr) with a number of amines and thio-carbohydrates. Subsequently, the antibacterial phototoxic activity of these BODIPYs has been assessed in bacterial assays against the Gram-positive germ S. aureus and also against the Gram-negative germ P. aeruginosa. The bacterial assays allowed to identify substitution patterns which ensured antibacterial activity not only in phosphate-buffered saline (PBS) but also in the presence of serum, hereby more realistically modelling the complex biological environment that is present in clinical applications. | en |
dc.format.extent | 2416-2431 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Organic and Biomolecular Chemistry; | |
dc.relation.ispartofseries | 18; | |
dc.relation.ispartofseries | 13; | |
dc.rights | Y | en |
dc.subject | thio-carbohydrates | en |
dc.subject | BODIPYs | en |
dc.subject | antimicrobial photodynamic therapy (aPDT) | en |
dc.subject.lcsh | thio-carbohydrates | en |
dc.subject.lcsh | BODIPYs | en |
dc.subject.lcsh | antimicrobial photodynamic therapy (aPDT) | en |
dc.title | Exploring the relationship between structure and activity in BODIPYs designed for antimicrobial phototherapy | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | |
dc.identifier.rssinternalid | 224221 | |
dc.identifier.doi | http://dx.doi.org/10.1039/d0ob00188k | |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsor | Science Foundation Ireland | en |
dc.contributor.sponsorGrantNumber | IvP 13/IA/1894 | en |