dc.contributor.author | Richards, Derek | |
dc.date.accessioned | 2021-04-11T08:58:04Z | |
dc.date.available | 2021-04-11T08:58:04Z | |
dc.date.issued | 2021 | |
dc.date.submitted | 2021 | en |
dc.identifier.citation | Franklin, M., Enrique, A., Palacios, J., Richards, D., Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression: construct validity and responsiveness, Quality of Life Research, 2021 Apr 9:1–15 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/96019 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Purpose: Generic health measures have been questioned for quantifying mental-health-related outcomes. In patients with anxiety and/or depression, our aim is to assess the psychometric properties of the preference-based EQ-5D-5L (generic health) and ReQoL-UI (recovery-focussed quality of life) for economic evaluation against the PHQ-9 (depression) and GAD-7 (anxiety). EQ-5D-5L anxiety/depression item and ReQoL-10 are also assessed.
Methods: A 2:1 (intervention: control) randomised controlled trial collected measures at baseline and 8 weeks post baseline; in the intervention arm, data were also collected 3, 6, 9, and 12-months post baseline. EQ-5D-5L preference-based scores were obtained from the value set for England (VSE) and 'cross-walked' EQ-5D-3L United Kingdom (UK) value set scores. ReQoL-UI preference-based scores were obtained from its UK value set as applied to seven ReQoL-10 items. EQ-5D-5L and ReQoL measures' construct validity and responsiveness were assessed compared against PHQ-9 and GAD-7 scores and group cut-offs.
Results: 361 people were randomised to intervention (241) or control (120). ReQoL-UI/-10 had better construct validity with depression severity than the EQ-5D-5L (VSE/cross-walk scores), which had relatively better construct validity with anxiety severity than the ReQoL-UI/-10. Across all intervention-arm time-points relative to baseline, responsiveness was generally better for EQ-5D-5L (VSE in particular) than ReQoL-UI, but worse than ReQoL-10.
Conclusion: There is insufficient evidence to recommend the ReQoL-UI over EQ-5D-5L for economic evaluations to capture anxiety severity. However, there may be rationale for recommending the ReQoL-UI over the EQ-5D-5L to capture depression severity given its better construct validity, albeit poorer responsiveness, and if recovery-focussed quality of life relative to condition-specific symptomology is the construct of interest. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Quality of Life Research; | |
dc.rights | Y | en |
dc.subject | Anxiety | en |
dc.subject | Depression | en |
dc.subject | EQ-5D-5L | en |
dc.subject | Economic evaluation | en |
dc.subject | Psychometrics | en |
dc.subject | ReQoL-10 | en |
dc.subject | ReQoL-UI | en |
dc.title | Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression: construct validity and responsiveness | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/drichard | |
dc.identifier.rssinternalid | 226954 | |
dc.identifier.doi | https://doi.org/10.1007/s11136-021-02833-1 | |
dc.rights.ecaccessrights | openAccess | |
dc.identifier.orcid_id | 0000-0003-0871-4078 | |
dc.subject.darat_thematic | Health | en |
dc.status.accessible | N | en |