dc.contributor.author | Mills, Kingston | |
dc.date.accessioned | 2021-09-29T14:05:36Z | |
dc.date.available | 2021-09-29T14:05:36Z | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020 | en |
dc.identifier.citation | McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG. Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity. 2020 Feb 18;52(2):342-356.e6 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/97198 | |
dc.description.abstract | Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at induction of experimental autoimmune encephalomyelitis (EAE) are resistant to disease and have defective priming of IL-17-secreting γδ T (γδT17) cells and Th17 cells. However, T cells from Il17a-/- mice induce EAE in wild-type mice following in vitro culture with autoantigen, IL-1β, and IL-23. Furthermore, treatment with IL-1β or IL-17A at induction of EAE restores disease in Il17a-/- mice. Importantly, mobilization of IL-1β-producing neutrophils and inflammatory monocytes and activation of γδT17 cells is reduced in Il17a-/- mice. Our findings demonstrate that a key function of IL-17A in central nervous system (CNS) autoimmunity is to recruit IL-1β-secreting myeloid cells that prime pathogenic γδT17 and Th17 cells. | en |
dc.format.extent | 342-356.e6 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Immunity; | |
dc.relation.ispartofseries | 52; | |
dc.relation.ispartofseries | 2; | |
dc.rights | Y | en |
dc.subject | vitroculture | en |
dc.subject | Interleukin-17A (IL-17A) | en |
dc.subject | autoimmune diseases | en |
dc.subject | IL-17 | en |
dc.subject | IL-1β | en |
dc.subject | Th17 cells | en |
dc.subject | Autoimmunity | en |
dc.subject | Experimental autoimmune encephalomyelitis | en |
dc.subject | Inflammatory monocyte | en |
dc.subject | Multiple sclerosis | en |
dc.subject | γδ T cells | en |
dc.subject | Neutrophil | en |
dc.title | Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/millsk | |
dc.identifier.rssinternalid | 220286 | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.immuni.2020.01.002 | |
dc.rights.ecaccessrights | openAccess | |
dc.identifier.orcid_id | 0000-0003-3646-8222 | |
dc.contributor.sponsor | Science Foundation Ireland | en |
dc.contributor.sponsorGrantNumber | 11/PI/ 1036 | en |