dc.contributor.author | Scanlan, Eoin | |
dc.date.accessioned | 2022-05-06T14:12:04Z | |
dc.date.available | 2022-05-06T14:12:04Z | |
dc.date.issued | 2022 | |
dc.date.submitted | 2022 | en |
dc.identifier.citation | Nolan, M.D. and Mezzetta, A. and Guazzelli, L. and Scanlan, E.M., Radical-mediated thiol–ene ‘click’ reactions in deep eutectic solvents for bioconjugation, Green Chemistry, 2022, 24, 4, 1456-1462 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/98542 | |
dc.description.abstract | Herein, we report the first application of deep eutectic solvents
(DESs) in radical-mediated hydrothiolation reactions. Under UV
and atmospheric-oxygen mediated conditions, the thiol–ene reac tion was applied to amino acid and peptide ligation in DESs. The
conditions facilitate highly-efficient synthesis of biomolecular
targets using a ‘green’ methodology, with complete recycling of
the reaction medium. Fluorescent labelling and glycosylation of a
minimal sequence mimetic of angiotensin-converting enzyme 2
capable of binding the SARS-CoV-2 spike protein is demonstrated
for applications in the study of inhibition of COVID-19 infectivity | en |
dc.format.extent | 1456-1462 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Green Chemistry; | |
dc.relation.ispartofseries | 24; | |
dc.relation.ispartofseries | 4; | |
dc.rights | Y | en |
dc.subject | COVID-19 infectivity | en |
dc.subject | deep eutectic solvents | en |
dc.subject | ‘green’ methodology | en |
dc.title | Radical-mediated thiol–ene ‘click’ reactions in deep eutectic solvents for bioconjugation | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/scanlae | |
dc.identifier.rssinternalid | 242713 | |
dc.identifier.doi | http://dx.doi.org/10.1039/d1gc03714e | |
dc.rights.ecaccessrights | openAccess | |
dc.identifier.orcid_id | 0000-0001-5176-2310 | |