Browsing Clinical Medicine (Theses and Dissertations) by Title
Now showing items 1-20 of 311
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A novel inflammatory mediator in sinus disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
Acute Stroke Care in Ireland - The Role of a National Audit in Improving Care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: The 2008 Irish national audit of stroke service (INASC) showed large deficits in service provision and access. A national stroke programme emerged to develop services and address these deficits. The country ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Advanced histology methods for biodistribution and safety screening of next generation nanobiomaterials
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Over the past few decades nanobiomaterials (NBMs) have shown a promise in improving many areas of medicine such as diagnosis and treatment of diseases, with number of formulations currently approved for use by the regulators. ... -
The altered immune microenvironment of human liver in metastatic disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Globally, metastatic colon cancer is a significant disease with poor outcomes. Liver metastases are the leading cause of death and, despite maximal medical management, recurrent metastases are seen in up to 70% of patients ... -
Alternative therapeutics for oesophageal cancer : novel toxic bile acid derivatives to induce apoptosis and siRNA library screen to identify genes that regulate cell shape
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ... -
An extensive evaluation of the validity of reported energy intakes in the North/South Ireland food consumption survey
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between 1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland and Northern Ireland, aged 18 to 64 years. Food intakes ... -
An in vivo study of utricular hair cell degeneration and regeneration following animoglycoside induced damage of the mammalian inner ear
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ... -
An investigation into novel components and signalling mechanisms of inflammasomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ... -
An investigation of risk factors for fracture in patients with osteoporosis and osteopaenia using biomechanical, biochemical and radiological assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ... -
An investigation of T lymphocyte migration induced by CD44 activation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ... -
An Analysis of the Biopsychosocial Factors including Sex and Pregnancy in Women with Axial Spondyloarthritis; Data from the Ankylosing Spondylitis Registry of Ireland (ASRI)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With advances in pathophysiology, development of novel classification criteria and the advent of new therapeutic agents the field of axial spondyloarthritis (axSpA) is rapidly evolving. Despite this, the impact and interplay ... -
Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ...