Pharmacy and Pharmaceutical Sciences (Theses and Dissertations)
Recent Submissions
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Using in vitro and in silico approaches to investigate ibuprofen particulate and formulation dissolution behaviour under different hydrodynamic conditions.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This work investigated the effect of fluid velocity and medium viscosity on the dissolution of ibuprofen powder and ibuprofen immediate release tablets in vitro, in the paddle apparatus and the flow-through apparatus, and ... -
The treatment of obesity using magneto -mechanical effect
Obesity is a very prevalent condition that can be very often associated with the development of comorbidities, such as insulin resistance, hypertension, and hyperlipidaemia that can lead to cardiovascular and cerebrovascular ... -
A mixed-methods approach to explore the association between age and medication -related problems among adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)General introduction Much attention was focused on the ageing phenomenon and how to improve the quality of life in older people. Medication-related problems (MRPs) can potentially lead to hospital admissions, increased ... -
Development and preliminary evaluation of OPTI-3S: A deprescribing support tool for hospitalised frail older adults.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)Introduction: In frail older people, polypharmacy (5 or more regular prescribed medicines) and the prescription of potentially inappropriate medicines (PIMs) are known to be prevalent and linked to negative clinical outcomes. ... -
Mesoporous Silica Nanocarriers for triggered drug delivery in the treatment of cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Cancer is the second leading cause of death globally, accounting for 10 million deaths in 2020. Cancer chemotherapy is currently limited by a high systemic toxicity that occurs as a result of high systemic dosing and the ... -
A theory-based exploration of the medicines management process provided to older people residing in the nursing home setting in the Republic of Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Introduction While the population is ageing globally, this does not necessarily mean that they are living healthier. The multimorbidity and polypharmacy in the older population (age> 65 years) increases their risk of ... -
Deprescribing Falls Risk Increasing Drugs in Older Adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Aim: The purpose of this thesis was to examine the facilitators of, and barriers to, implementing deprescribing of falls risk increasing medicines (FRIDs) in healthcare professionals' practices, by exploring the perspectives ... -
Deciphering the interplay of extracellular vesicles and drug resistance in HER2-positive breast cancer: insights, biomarkers and therapeutic implications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)According to a World Health Organisation (WHO) report on 3rd March 2021, breast cancer is the most common form of cancer in the world and the leading cause of cancer death among females. In 2020, 2.26 million newly breast ... -
Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs).
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)This project aims to develop a drying protocol that removes unwanted moisture from hydrated APIs while preserving water of hydration. Hydrate forms of model compounds, carbamazepine and theophylline, were generated with ... -
Milking extracellular vesicles for health benefit using a multi-omics approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Milk is remarkable source of nutrients (i.e., proteins, fat, and sugars) and extracellular vesicles (EVs). EVs are tiny vesicles release by cells into all biofluids including milk. Milk EVs have been gathered huge attention ... -
Exploring Membrane Transporters in Lung Epithelial Cells: Drug-Transporter Interaction Analyses in Different In Vitro Models
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Over the last decade, the incidence of lung-related diseases such as asthma and chronic obstructive pulmonary disease and their associated morbidity have continuously risen. A heterogeneity in treatment response to commonly ... -
Mechanochemical Synthesis and Physicochemical Characterisation of Multicomponent Phases Comprising Lidocaine and Dicarboxylic Acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Tuning of physicochemical properties of multicomponent phases incorporating active pharmaceutical ingredients (APIs) with counterions or coformers is a challenge that opens up unlimited possibilities for expanding applications ... -
Improving appropriate polypharmacy in older people in primary care
Introduction People are living longer but not necessarily in better health. The ageing population coupled with the increasing prevalence of chronic conditions has resulted in many older people being prescribed polypharmacy ... -
Enantioseparation and structural optimisation of b-lactams and stilbene analogues for the treatment of triple negative breast and chemoresistant colorectal cancers
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Triple negative breast cancer (TNBC) is characterised by an extremely aggressive clinical phenotype and minimal expression of typical breast cancer receptors such as the estrogen, progesterone or HER2 receptors.1, 2 Patient ... -
A journey from ethnomedicine in rural Kenya to network pharmacology using a critical research approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Background: Traditional medicine (TM) is widely practiced globally, with inter-country figures on usage ranging from 30 to 90%. Research on TM is conducted for a multiplicity of reasons, among them health care and ... -
A Precision Medicine Approach to Natriuretic Peptide-Guided Risk Prediction and Treatment: A Retrospective Analysis in the STOP-HF Cohort
Introduction: Individual studies show that NP-guided treatment is an effective intervention for the prevention of HF. We hypothesised that this approach may be optimised utilising a precision medicine approach. Methods: ... -
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
Characterisation of Depressive Symptoms in Huntington's Disease and of the Pharmacological Treatment for Depression: patterns, trends and Statistical Analysis of Enroll-HD Dataset
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: Huntington?s Disease (HD) is a rare autosomal dominant genetic disorder characterised by a triad of motor, psychiatric and cognitive symptoms. Among the psychiatric manifestations, depression is very common and ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
Patterns of Medication Use Associated with Epilepsy and Comorbid Behavioural and Mental Disorders in Older People with Intellectual Disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: There is increasing concern worldwide regarding the levels of use and suboptimal prescribing of psychotropic medication in people with intellectual disability. Antipsychotics, in particular are often prescribed ...