Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 579-598 of 640
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Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ... -
Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
(2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ... -
The design and synthesis of novel inhibitors of tubulin polymerisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis is introduced with a review on the principles of tubulin polymerisation and how this process is necessary for cellular replication. This leads on to discussion of the structure-activity relationships of known ... -
The design, implementation, and evaluation of a medication safety programme in an acute Irish teaching hospital
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The research undertaken for this thesis aimed to address the current deficit which exists in relation to the status of medication safety in Irish hospitals and add to the limited body of published data available from any ... -
The design, synthesis and biochemical evaluation of analogues of dehydroepiandrosterone (DHEA) and novel selective oestrogen receptor modulators (SERMs)
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)This thesis is presented in four sections. In the first section the synthesis of a series of B ring derivatives of dehydroepiandrosterone (DHEA) is described. DHEA is the most abundant steroid in human plasma and has been ... -
The design, synthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)This thesis is presented in four different sections. In the first section the synthesis of a number of structural (novel flexible) analogues of the antiestrogen drug tamoxifen is described. Preparation of novel conformationally ... -
The design, synthesis and biological effects of novel steroid prodrugs for treatment of gastrointestinal diseases
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The aim of the work described in this thesis was to synthesize and test the biological effects of a novel type of prodrug to deliver steroids to the colon for the treatment of gastrointestinal diseases. Glucocorticoids are ... -
The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Matrix metalloproteinases (MMPs) are a group of Zn-dependent endopeptidases that participate in many diseases. Two MMPs, MMP-2 and MMP-9, which are especially associated with inflammatory diseases and tumor metastasis have ... -
The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The purpose of the work undertaken within this project was to design and synthesis novel anti-cancer targeting compounds building upon previous work undertaken under the supervision of Dr. John J. Walsh in the School of ... -
The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The objective of this project was to design, synthesise and carry out preliminary evaluations on potential prodrugs and hybrid drugs with anti-proliferative effects. Chapter 1 gives an overview of current trends in cancer ... -
The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Combretastatin A-4 (CA4) is a natural product first isolated from the Combretum caffrum South African willow tree by Pettit and co-workers. CA4 has proved to be a potent antimitotic agent, with a mechanism of action ... -
The development, validation and application of analytical methods for the analysis of drugs of abuse
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)There are five chapters presented in this thesis. The first chapter deals with development and validation of a HPLC method for the analysis of MDMA in illicitly produced Ecstasy tablets. In all 100 tablets were analysed ... -
The effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The purpose of the research presented in this thesis was to produce metastable active pharmaceutical ingredients (API) by spray drying and to analyse, physico-chemically characterise these forms and develop strategies to ... -
The influence of drug physicochemical properties on release from thermoresponsive smart hydrogels
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Thermoresponsive hydrogels are a class of "smart" or "environmentally sensitive" systems with potential for controlling the release of a drug in response to a specific stimulus. Previous research in the area of thermoresponsive ... -
The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)There is a constant drive towards improving global health by continuously enhancing the quality of drugs available and the systems to deliver these drugs efficiently in order to treat disease. This thesis focused on the ... -
The pharmacological and toxicological effects of polystyrene and silica nanoparticles on human airway epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: A number of lung pathologies are associated with the dysfunction of ion flux through pulmonary epithelium. Cystic fibrosis (CF) is a chronic and life-threatening genetic disease that directly affects ... -
The pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)This study sought to determine the pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors (BuChEl’s) in vitro and in vivo. The potency of the novel compounds 2-benzylcarbamate 5-nicotinate ... -
The production and characterisation of spray dried nanoporous microparticles (NPMPs) intended for dry powder inhalation drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential application of a novel spray drying method to produce excipient-free nanoporous microparticles (NPMPs) of bioactive drug compounds and co-spray dried ...