Browsing by Subject "Chemistry, Ph.D."
Now showing items 1-8 of 8
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Biological investigations of novel 1,8-naphthalimide compounds and the design and synthesis of pyridine based polyamides
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)This thesis entitled "Biological Investigations of Novel 1,8-Naphthalimide Compounds and the Design and Synthesis of Pyridine Polyamides" is divided into six chapters. Chapter 1, the introduction focuses on the basic ... -
Novel system development for combined scanning tunneling microscopy & surface stress measurements to investigate the origins of surface forces
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The oxidation of the silicon surface has been widely studied due to its vast scientific and technological importance. However, despite extensive work on the topic the exact details of the oxidation reaction still remain a ... -
Strategies towards the synthesis of linear tetrapyrroles and the reactions of substituted pyrroles with sulfuryl chloride
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The research undertaken in the present study describes the synthesis of bilins from easily obtainable starting materials using robust methods and the unusual reaction of SO2CI2 with tetrasubstituted pyrroles. -
Synthesis and biological activity of 9-Azapaullone, its N-oxide and N-benzyl derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Cancer is a serious and life-threatening disease that accounts for 13% of deaths each year. It is a complicated process with many factors and variations observed, however research has uncovered many new strategies for the ... -
Synthesis and evaluation of cyclen-based lanthanide complexes for luminiscent sensing and as MRI contrast agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis entitled "The Synthesis and Evaluation of Cyclen Based Lanthanide Complexes for Luminescent Sensing and as MRI Contrast Agents" is composed of five chapters. In the first chapter the photophysical properties ... -
Synthesis and photophysical investigation of novel supramolecular lanthanide luminescent architectures
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis is entitled "Synthesis and photophysical investigations of novel supramolecular architectures" and is composed of five chapters. In the first chapter the photopysical and chemical properties of the lanthanide ... -
Synthesis of nitropyrimidines as inactivators of 0-6-Methylguanine-DNA Methyltransferase
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The cytotoxic effects of the chemotherapeutic N-(2-chloroethyl)-N-nitrosoureas (e.g. BCNU, CCNU, fotemustine) and the related methylating agents (e.g. DTIC, procarbazine, temozolomide) are primarily a consequence of their ... -
Synthetic investigations towards the preparation of novel tetracycline antibiotics
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)This research initially concerned itself with the synthesis of a dimeric compound of tetracycline antibiotics linked by a flexible tether. Tetracycline antibiotics have been in use since their discovery in the 1940s but ...