Browsing by Subject "DNA"
Now showing items 1-17 of 17
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Ab initio study of electron transport in dry poly(G)-poly(C) A-DNA strands
(2010)The bias-dependent transport properties of short poly (G)-poly(C) A-DNA strands attached to Au electrodes are investigated with first-principles electronic-transport methods. By using the nonequilibrium Green's function ... -
Asymmetrical Diaromatic Guanidinium/2-Aminoimidazolinium Derivatives: Synthesis and DNA Affinity
(2009)In this paper we report the synthesis of three families of new amidine?based aromatic derivatives as potential DNA minor groove binding agents for the treatment of cancer. The preparation of mono?guanidine, mono?2?aminoimidazoline ... -
Building unique bonds to fight misplaced DNA
(2013)A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
Correction: Glycosylated naphthalimides and naphthalimide Tröger’s bases as fluorescent aggregation probes for Con A
(Royal Society of Chemistry, 2019) -
The effect of the 4-amino functionality on the photophysical and DNA binding properties of alkyl-pyridinium derived 1,8-naphthalimides
(2013)The synthesis and characterisation of two cationic pyridinium based 4-amino-1,8-naphthalimide derivatives (2 and 3) are described and compared to those of compound 1. The photophysical properties of 2 and 3 are shown to ... -
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein–DNA and protein–protein interactions is ... -
H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast
(2011)Background The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional ... -
Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a RuII Complex due to Structural Change in the Minor Groove
(2017)Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. For the photo-oxidising lambda-[Ru(TAP)2 ... -
Long-lived excited state dynamics of i-motif structures probed by time-resolved infrared spectroscopy
(2016)UV‐generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i‐motif formed from C‐rich sequences is known to exhibit high yields of long‐lived excited states following ... -
Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
(2013)If DNA accumulates in the cytosol it activates innate immunity via recently described DNA sensors. In this issue of Immunity Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has ... -
Ruthenium Polypyridyl Complexes for Biological Applications in Imaging and as Anti-Cancer Agents
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)Ruthenium-polypyridyl complexes containing extended aromatic ring systems exhibit attractive photophysical properties and have been shown to bind strongly to DNA. Such properties make complexes like these suitable for a ... -
Spectroscopic and Crystallographic Evaluation of Ruthenium(II) Complexes Bearing Phenanthroline-Naphthalimide Ligands
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Spectroscopic and Crystallographic Evaluation of Ruthenium(II) Complexes Bearing Phenanthroline-Naphthalimide Ligands Deirdre Ann McAdams This Thesis predominantly focusses on the design, synthesis, and characterisation ... -
Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution
(2009)2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis 2-amino-4,5,6-trichloropyrimidine ... -
Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
(2013)The bi-functional complex [PtII(terpy)(py-naphth)](NO 3)2(1), incorporating both 2,2?:6?, 2??-terpyridine and 4-N,N?-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying ...