Building unique bonds to fight misplaced DNA
Citation:
Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research, 23, 9, 2013, 1065-1066Download Item:
Abstract:
A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and identifies this cyclic dinucleotide as a unique compound in metazoan cell signaling.
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Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/laoneillDescription:
PUBLISHED
Author: O'NEILL, LUKE
Type of material:
Journal ArticleCollections
Series/Report no:
Cell Research23
9
Availability:
Full text availableKeywords:
DNASubject (TCD):
Cancer , Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1038/cr.2013.81Metadata
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