dc.contributor.author | Romero-Ortuno, Roman | |
dc.date.accessioned | 2023-03-04T14:14:50Z | |
dc.date.available | 2023-03-04T14:14:50Z | |
dc.date.issued | 2023 | |
dc.date.submitted | 2023 | en |
dc.identifier.citation | Travers J, Romero-Ortuno R, Langan J, MacNamara F, McCormack D, McDermott C, McEntire J, McKiernan J, Lacey S, Doran P, Power D, Cooney MT, Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults, Age and Ageing, 2023, 52: 1–9 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/102229 | |
dc.description.abstract | Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience.
Objective: To study the effectiveness of an optimised exercise and dietary protein intervention.
Design: Multicentre, randomised-controlled, parallel-arm trial.
Setting: Six primary care practices, Ireland.
Methods: Six general practitioners enrolled adults aged 65+ with Clinical Frailty Scale score ≤5 from December 2020 to
May 2021. Participants were randomised to intervention or usual care with allocation concealed until enrolment. Intervention
comprised a 3-month home-based exercise regime, emphasising strength, and dietary protein guidance (1.2 g/kg/day).
Effectiveness was measured by comparing frailty levels, based on the SHARE-Frailty Instrument, on an intention-to-treat
basis. Secondary outcomes included bone mass, muscle mass and biological age measured by bioelectrical impedance analysis.
Ease of intervention and perceived health benefit were measured on Likert scales.
Results: Of the 359 adults screened, 197 were eligible and 168 enrolled; 156 (92.9%) attended follow-up (mean age 77.1;
67.3% women; 79 intervention, 77 control). At baseline, 17.7% of intervention and 16.9% of control participants were frail
by SHARE-FI. At follow-up, 6.3 and 18.2% were frail, respectively. The odds ratio of being frail between intervention and
control groups post-intervention was 0.23 (95% confidence interval: 0.07–0.72; P = 0.011), adjusting for age, gender and
site. Absolute risk reduction was 11.9% (CI: 0.8%–22.9%). Number needed to treat was 8.4. Grip strength (P < 0.001) and
bone mass (P = 0.040) improved significantly. 66.2% found the intervention easy, 69.0% reported feeling better.
Conclusion: A combination of exercises and dietary protein significantly reduced frailty and improved self-reported health. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Age and Ageing; | |
dc.rights | Y | en |
dc.subject | Frailty | en |
dc.subject | Resilience | en |
dc.subject | Primary care | en |
dc.subject | Exercise | en |
dc.subject | Protein | en |
dc.subject | Older people | en |
dc.title | Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/romeroor | |
dc.identifier.rssinternalid | 249782 | |
dc.identifier.doi | https://doi.org/10.1093/ageing/afad012 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Ageing | en |
dc.identifier.orcid_id | 0000-0002-3882-7447 | |
dc.subject.darat_impairment | Age-related disability | en |
dc.subject.darat_impairment | Chronic Health Condition | en |
dc.subject.darat_impairment | Mental Health/Psychosocial disability | en |
dc.subject.darat_impairment | Physical disability | en |
dc.subject.darat_thematic | Community | en |
dc.subject.darat_thematic | Health | en |
dc.subject.darat_thematic | Third age/ageing | en |
dc.status.accessible | N | en |
dc.contributor.sponsor | Health Research Board (HRB) | en |
dc.contributor.sponsorGrantNumber | CTN-2014-011 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 18/FRL/6188 | en |