School of Medicine
Academic/Research Units within this Academic/Research Unit
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Anatomy
Anatomy -
Clinical Medicine
Clinical Medicine -
Clinical Microbiology
Clinical Microbiology -
Haematology
Haematology -
Histopathology & Morbid Anatomy
Histopathology & Morbid Anatomy -
Immunology
Immunology -
Medical Gerontology
Medical Gerontology -
Obstetrics & Gynaecology
Obstetrics & Gynaecology -
Occupational Therapy
Occupational Therapy -
Ophthalmology
Ophthalmology -
Paediatrics
Paediatrics -
Pharmacology & Therapeutics
Pharmacology & Therapeutics -
Physiology
Physiology -
Physiotherapy
Physiotherapy -
Psychiatry
Psychiatry -
Public Health & Primary Care
Public Health & Primary Care -
Radiation Therapy
Radiation Therapy -
Surgery
Surgery
Recent Submissions
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Clinicoradiological outcomes after radical radiotherapy for lung cancer in patients with interstitial lung disease.
(2023)Objective: Interstitial lung disease (ILD) is relatively common in patients with lung cancer with an incidence of 7.5%. Historically pre-existing ILD was a contraindication to radical radiotherapy owing to increased radiation ... -
Cardiovascular autonomic function and progression of age-related macular degeneration in The Irish Longitudinal Study of Ageing (TILDA)
(2024)Purpose: To examine if changes in hemodynamic measures during an orthostatic challenge were associated with progression of age-related macular degeneration (AMD) over a 4-year period in The Irish Longitudinal Study on ... -
Comparing Face-to-Face, Blended and Online Teaching Approaches for Practical Skill Acquisition: A Randomised Controlled Trial
(2024)Introduction: The efficacy of blended and online teaching methods for practical skill acquisition remains ambiguous, particularly for skills requiring haptic awareness and/or sensory training. This study aims to compare ... -
Diagnostic accuracy of 18F Prostate Specific Membrane Antigen (PSMA) PET-CT radiotracers in staging and restaging of high-risk prostate cancer patients and patients with biochemical recurrence: protocol for an overview of reviews
(2023)Background: Correct staging and risk stratification is essential in ensuring prostate cancer patients are offered the most appropriate treatment. Interest has been growing in the use of radiotracers targeting prostate ... -
Diagnostic accuracy of 18F Prostate Specific Membrane Antigen (PSMA) PET-CT radiotracers in staging and restaging of high-risk prostate cancer patients and patients with biochemical recurrence: an overview of reviews
(Seminars in Nuclear Medicine, 2024)The aim of this overview was to consolidate existing evidence syntheses and provide a comprehensive overview of the evidence for 18F-prostate specific membrane antigen (PSMA) PET/CT in the staging of high-risk prostate ... -
Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
Outcomes of the LEAP feasibility trial - a low-threshold, exercise programme with protein supplementation to target frailty and poor physical functioning in people experiencing homelessness and addiction issues
(2024)Background: People experiencing homelessness are more likely to experience poor health with physical functioning deficits and frailty commonly reported. It is not well known how strategies to target physical functioning ... -
A qualitative study exploring policy-amenable factors influencing medical device-related patient safety from a lifecycle perspective
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2024)Thesis Title: A qualitative study exploring policy-amenable factors influencing medical device-related patient safety from a lifecycle perspective Author: Kathleen Rose Harkin Abstract Introduction: Medical devices ... -
Biomarker discovery in non-small cell lung cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)In Ireland, lung cancer represents the third most common cancer, after breast and prostate cancer. Major improvements have been made in treating this disease with the advent of targeted therapies and immunotherapy. These ... -
The Role of Intermediaries in Connecting Community-Dwelling Adults to Local Physical Activity and Exercise: A Scoping Review
(2024)Introduction: Connecting inactive individuals to local physical activity (PA) and exercise, via intermediaries (professionals who can facilitate and support connections to non-medical services) may be an effective method ... -
The impact of Esophageal Oncological Surgery on perioperative immune function; implications for adjuvant immune checkpoint inhibition
(2022)Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains ... -
Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses
(2023)The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study ... -
Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
(2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ... -
Incidence and Impact of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients with Adenocarcinoma of the Esophagus Treated with Curative Intent
(2022)Background and aims: Esophageal adenocarcinoma (EAC) is associated with visceral obesity (VO). Non-alcoholic fatty liver disease (NAFLD) is common within this phenotype; however, its incidence and clinical significance in ... -
Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses
(2023)Glioblastoma multiforme (GBM) is the most common adult primary brain malignancy, with dismal survival rates of ~14.6 months. The current standard-of-care consists of surgical resection and chemoradiotherapy, however the ... -
Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma.
(2024)The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve ... -
Natural killer cell therapy: A new frontier for obesity-associated cancer
(2022)Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing augmentation of NK cell abundance in tumours as an attractive immunotherapeutic approach. The unique ability of NK cells ... -
Harnessing Natural Killer Cells in Non-small Cell Lung Cancer
(2022)Lung cancer is the leading cause of cancer-related deaths worldwide. There are two main subtypes: small cell lung cancer (SCLC), and non-small cell lung cancer (NSCLC). NSCLC accounts for 85% of lung cancer diagnoses. Early ... -
Existing evidence for the repurposing of PARP-1 inhibitors in rare demyelinating diseases
(2022)Over the past decade, Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have arisen as a novel and promising targeted therapy for breast cancer gene (BRCA)-mutated ovarian and breast cancer patients. Therapies targeting ...