Clinical Microbiology
Collections in this Academic/Research Unit
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Clinical Microbiology (Live Theses)
Clinical Microbiology (Live Theses) -
Clinical Microbiology (Scholarly Publications)
Clinical Microbiology (Scholarly Publications) -
Clinical Microbiology (Theses and Dissertations)
Clinical Microbiology (Theses and Dissertations)
Recent Submissions
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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.
(2022)Many bacterial pathogens antagonize host defense responses by translocating effector proteins into cells. It remains an open question how those pathogens not encoding effectors counteract anti-bacterial immunity. Here, we ... -
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation
(2021)The formation of Ca2+ microdomains during T cell activation is initiated by the production of nicotinic acid adenine dinucleotide phosphate (NAADP) from its reduced form NAADPH. The reverse reaction—NAADP to NAADPH—is ... -
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
(2019)Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β ... -
SARM: from immune regulator to cell executioner
(2019)SARM is the fifth and most conserved member of the Toll/Il-1 Receptor (TIR) adaptor family. However, unlike the other TIR adaptors, MyD88, Mal, TRIF and TRAM, SARM does not participate in transducing signals downstream of ... -
Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.
(2018)Host pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) detect viruses and other pathogens, inducing production of cytokines that cause inflammation and mobilize cells to control infection. Vaccinia ... -
Innate antiviral signalling in the central nervous system.
(2014)The innate immune system mediates protection against neurotropic viruses capable of infecting the central nervous system (CNS). Neurotropic viruses include herpes simplex virus (HSV), West Nile virus (WNV), rabies virus, ... -
Diverse Roles for the Extracellular Glycome of Extra-intestinal Pathogenic Escherichia coli in Serum Resistance and more
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2023)Extra-intestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections, bacteraemia, and sepsis. This laboratory, among others, has previously shown that prototypic urosepsis strain CFT073 is ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ... -
Evaluation of an in-house six-well screening plate as a means of detecting phenotypic triazole resistance in St. James's Hospital, Dublin with emphasis on Aspergillus fumigatus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2022)Aspergillus fumigatus is a ubiquitous saprophytic mould fungus found in nature. This fungus is present in the air, in soil, in foliage in our food stock and on inanimate surfaces. For healthy individuals, A. fumigatus poses ... -
Investigating the Role of Extracellular Polysaccharides in Biofilm Formation of Klebsiella pneumoniae
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2020)Klebsiella pneumoniae (K. pneumoniae) is the most significant and clinically relevant species in the Klebsiella genus of Enterobacteriaceae and is the causative agent of a variety of infections, including pneumonia, urinary ... -
Development of a New Genome-Wide MLST Scheme for High-Resolution Typing of Diverse Mycobacterium tuberculosis Complex Strains
(2018)In this issue of EBioMedicine, Kohl and colleagues describe the development of a new core genome MLST scheme (cgMLST) for Mycobacterium tuberculosis complex strains based on a set of 2891 genes. Here, the application of ... -
Regulation of Antigen 43, a phase-variable autoaggregation factor of Escherichia coli
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)The Antigen 43 protein (Ag43) of Escherichia coli, encoded by the agn43 gene, has previously been shown to be expressed in a phase-variable manner. A plasmidborne fusion of the agn43 regulatory region to the reporter gene ... -
Inhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2005)The induction of cytopathic effects in tumour cells, often by apoptosis, is the primary goal of most non-surgical cancer therapies. Cancer gene therapy represents a variety of potentially therapeutic strategies involving ... -
Characterisation of the Elastin Binding Protein (EbpS) of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Staphylococcus aureus expresses an array of surface proteins that promote interaction of the bacterium with the host. Some surface proteins promote binding to components of the host extracellular matrix and can act as ... -
Analysis and development of the recombinant Semliki Forest virus vector as a cancer gene therapy agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Increased understanding of the molecular pathogenesis of cancer has shown that its accumulation is the result of multiple genetic alterations. Cancer is a disease of altered genes, with the most predominantly altered ... -
The molecular characterization of the clumping Factor A (ClfA) from Staphylococcus aureus using monoclonal antibodies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2000)Clumping factor (ClfA) of Staphylococcus aureus is the major fibrinogen- binding adhesin located on the cell surface of the bacterium. Monoclonal antibodies (mAbs) were produced to two recombinant truncated ClfA proteins, ... -
Functional analysis of the VirB protein of Shigella flexneri
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)The VirB protein is a key regulator of virulence gene expression in Shigella flexneri, a facultative enteroinvasive pathogen that causes bacillary dysentery. Genetic evidence has shown that VirB is required for the activation ... -
A role for proteases and transcriptional regulation in the expression of ClfB on the surface of staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Staphylococcus aureus is an important human pathogen. This bacterium expresses proteins on its surface capable of binding to many host ligands including fibrinogen, fibronectin, collagen, elastin and von Willebrand factor. ... -
The control of DNA gyrase expression and its role in deletion formation in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)Salmonella typhimurium strain CJD671 can undergo the deletion of a 5kb segment of DNA from its large virulence plasmid. This results in a transcriptional fusion between the rlgA gene, encoding a putative site-specific ...