Browsing Chemistry (Theses and Dissertations) by Title
Now showing items 193-212 of 398
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New Approaches to the treatment of Schizophrenia and other Neuropsychiatric Disorders: Targeting alpha2-adrenoceptors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Schizophrenia is a severe mental illness affecting 21 million people worldwide, resulting in cognitive impairments and negative symptoms that impact patients' ability to live a normal life. Almost all current antipsychotic ... -
New carbon nanotube composites
(Trinity College (Dublin, Ireland). School of Chemistry, 2006)The main goal of this research is to prepare new chemically functionalised carbon nanotubes and their composite materials and to investigate their properties. This work is focused on the use of organometallic chemistry for ... -
New families of minor groove binders : synthesis, biophysical and biochemical evaluation and their role in apoptosis
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)There is an active field in the design and synthesis of DNA targeting molecules as potential anticancer agents. Although a number of successful drug treatments against a variety of cancers are in clinical use, many of these ... -
New magnetic nanocomposite materials
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)The main aim of this project is to develop new iron oxide based nanomaterials with potential biomedical applications. This work involves the synthesis of various magnetite, maghemite and cobalt ferrite nanocomposites, the ... -
New Materials for Controlled Singlet Oxygen Generation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Singlet oxygen is notoriously uncontrollable, suffers from poor selectivity, and has fast decomposition rates in biological media. Across the scientific community, there is an enduring effort to refine singlet oxygen ... -
New metallasiloxane complexes of aluminium and lanthanides
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)The main objective of this project was to develop novel metalIasiloxane complexes through a variety of synthetic strategies. The work focused mainly on aluminium and lanthanide metallasiloxanes. The catalytic properties ... -
New methodologies for catalysis and combinatorial chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The enantioselective synthesis of chiral molecules, such as those required by the pharmaceutical industry, is one of the most important tasks in chemistry. Asymmetric catalysis is an attractive way to synthesise enantiopure ... -
New N- and S-containing polyaryl compounds as ligands in transition-metal coordination chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 2005)Part 1 gives an overview of the literature concerning nitrogen-donor and thiophene ligands and their transition metal complexes. In particular it focuses on the known variations in the synthesis, design and coordination ... -
New studies in the synthesis and applications of pteridines
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The work described in this thesis involved the study of two distinct areas of research within pyrimidine and pteridine chemistry. The first of these involved investigation of the pteridine biosynthetic pathway within the ... -
New technology for the extraction of energy critical metals from weee and removal of PFOA from water
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)ABSTRACT Electrical and electronic equipment contains a plethora of energy critical metals which eventually concentrates in the annual 20-50 million metric tonnes of e-wastes produced globally. This has been identified ... -
Nitrogen containing aromatic ligands : nitrogen-heterosuperbenzene and derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)In Chapter 1, the potentially terdentate C,N,N' chelating monoanionic aryl diamine ligand "Diam" is manipulated, resulting in the synthesis of several novel compounds. This includes DiamZnEt, the first organometallic complex ... -
Nitrogenation of carbon surfaces via photoinduced reactions
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)Carbon based materials have emerged in last decades as a promising area of interest in the scientific research. Their wide range of applications goes from the biomedical to the energetic sector thanks to their incredibly ... -
Non-covalent interactions in supramolecular hybrid polyoxometalates
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)Polyoxometalates (POMs) are a species of discrete anionic polynuclear metal-oxo clusters made from early transition metals in their higher oxidation states. Together with organic ligands they can be assembled in hybrid ... -
Non-crystalline nitrogenated carbon electrode materials: Bulk and surface doping methods for controlling electrochemical properties
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)Carbon is ubiquitous as an electrode material and its electronic and capacitive properties and its surface chemistry are suitable for electrode materials for several applications such as fuel cells, capacitive storage ... -
Novel Approaches to Probe the Activity of Deubiquitinating Enzymes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Ubiquitination is a highly conserved post-translational modification that regulates a multitude of critical cellular events. This process is orchestrated by a complex enzymatic network. Deubiquitinating enzymes (DUBs) ... -
Novel bifunctional organocatalysts for enantioselective synthesis
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)Inspired by the efficiency and selectivity achievable by hydrogen bonding in biological catalysis, the work in this thesis is concerned with the application of these principles to the development of small chiral organic ... -
Novel biomimetic organocatalysts and asymmetric formal cycloaddition reactions using enolisable anhydrides as nucleophiles
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The synthesis of a biomimetic organocatalyst bearing functional groups mimicking the active residues in the active site of the oxidoreductase enzyme non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) has ... -
Novel btp [2,6-bis(1,2,3-triazol-4-yl)pyridine] systems: a versatile motif for the formation of supramolecular self-assembly structures
(Trinity College Dublin, 2015)This thesis, entitled “Novel btp [2,6-bis(1,2,3-triazol-4-yl)pyridine] systems: a versatile motif for the formation of supramolecular self-assembly structures” describes the synthesis and characterisation of a range of new ... -
Novel Chemical Modalities and Methods for Protein Profiling
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The activity of proteins is pivotal to the chemistry of cells. In order to deconvolute the complexity of living systems, chemical tools can be used to study active proteins under different cellular states. Amongst these ... -
Novel colorimetric and fluorescent sensors for anions
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis, entitled "Novel Colorimetric and Fluorescent Sensors for Anions" consists of six Chapters. Chapter 1 provides an introduction into the field of anion sensing using fluorescent and colorimetric sensors, within ...
