Clinical Medicine (Scholarly Publications)
Recent Submissions
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Supportive care: the "keystone" of modern oncology practice
(2023)The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and ... -
Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features ... -
Circadian rhythm disorders in patients with advanced cancer: a scoping review
(2023)Circadian rhythms can be demonstrated in several biomarkers and behavioural activities, with rhythmical patterns occurring roughly over a 24-h period. Circadian disorders occur in patients with cancer and may be associated ... -
Challenges to delivering evidence-based palliative medicine
(2023)Established as a medical specialty in 1987, palliative medicine approaches middle age facing existential questions of identity, purpose and vision. Time has weakened strong foundations laid by Dame Cicely Saunders in ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ... -
Vital signs in palliative care: a scoping review
(2023)Vital signs are routinely measured in secondary healthcare settings and can be used to detect clinical problems, guide treatment, and monitor response to treatment. Vital signs are less frequently measured in palliative ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
International e-Delphi consensus recommendations for the assessment and diagnosis of circadian rest-activity rhythm disorders (CARDs) in patients with cancer
(2023)Purpose: Circadian rest-Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ... -
Specialist palliative for patients with cancer: more than end-of-life care
(2023)Palliative care has traditionally focused on end-of-life care for patients with advanced cancer. This has since expanded to include symptom management and quality-of-life improvement from the moment of cancer diagnosis. ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ... -
Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review
(2023)Background and study aims Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images ... -
Estimation of coherence using the median is robust against EEG artefacts
(2017)Coherence is a mathematical measure of correlation in the frequency domain, commonly used to quantify the oscillatory synchrony of bio-signals such as the electroencephalogram (EEG). In biomedical applications, such as ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Clinically-assisted hydration in patients in the last days of life (?CHELSEA II? trial): a cluster randomised trial
(2022)Introduction Provision of clinically assisted hydration (CAH) at the end of life is one of the most contentious issues in medicine. The aim of the ‘CHELsea II’ trial is to evaluate CAH in patients in the last days of life. ... -
Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer
(2020)Sirtuin 1 (SIRT1) is a histone deacetylase (HDAC) from Sirtuin family and high expression of it induces activation of DNA repairing factors eventually leading either tumor suppression or tumor development in cellular ... -
Evaluation of the effect of solid and cationic lipids on siRNA delivery systems
(2020)This study aims to develop nanoparticles with different types of solid and cationic lipids and evaluate them as siRNA delivery systems. For this purpose, we prepared a series of lipid nanoparticles by combining cationic ... -
A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability
(2020)We aimed to develop nanostructured lipid carriers (NLCs) displaying similar characteristics – particle size, polydispersity index, and zeta potential – with the model solid lipid nanoparticles (SLNs) for better comparability. ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
(2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications
(2023)Purpose: In March 2020, a 1-week adjuvant breast radiotherapy schedule, 26 Gy in 5 fractions, was adopted to reduce the risk of COVID19 for staff and patients. This study quantifies acute toxicity rates and the effect ...