IL-10 inhibits miR-155 induction by Toll-like receptors.
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2010Citation:
McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, 27, 2010, 20492-20498Download Item:
Abstract:
IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs play a role in the inhibitory effect of IL-10 on TLR4 signalling. Analysing miRNAs known to be induced by TLR4, we found that IL-10 could inhibit the expression of miR-155 in response to LPS, but had no effect on miR-21 or miR-146a. IL-10 inhibited miR-155 transcription from the BIC gene in a STAT3 dependent manner. This inhibitory effect of IL-10 on miR-155 led to an increase in the expression of the miR-155 target gene, SHIP1. This is the first example of IL-10 playing a role in miRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression.
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Health Research Board (HRB)
European Union (EU)
Science Foundation Ireland (SFI)
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http://people.tcd.ie/laoneillhttp://people.tcd.ie/doyles8
http://people.tcd.ie/fsheedy
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Author: O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK
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The Journal of Biological Chemistry285
27
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anti-inflammatory gene expressionSubject (TCD):
Immunology, Inflammation & Infection , NeuroscienceDOI:
http://dx.doi.org/10.1074/jbc.M110.102111ISSN:
0021-9258Metadata
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