dc.contributor.author | GILL, MICHAEL | en |
dc.contributor.author | LAWLOR, BRIAN | en |
dc.date.accessioned | 2011-03-16T15:40:54Z | |
dc.date.available | 2011-03-16T15:40:54Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Proitsi P, Hamilton G, Tsolaki M, Lupton M, Daniilidou M, Hollingworth P, Archer N, Foy C, Stylios F, McGuinness B, Todd S, Lawlor B, Gill M, Brayne C, Rubinsztein DC, Owen M, Williams J, Craig D, Passmore P, Lovestone S, Powell JF, A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD)., Neurobiology of Aging, 32, 3, 2011, 434-442 | en |
dc.identifier.issn | 0197-4580 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/53324 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Introduction
Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little investigated.
Methods
We have analysed a sample of 1850 probable AD patients from the UK and Greece with 10 item Neuropsychiatric Inventory (NPI) data. We applied a Multiple Indicators Multiple Causes (MIMIC) approach to investigate the effect of MMSE, disease duration, gender, age and age of onset on the structure of a four-factor model consisting of ?psychosis?, ?moods?, ?agitation? and ?behavioural dyscontrol?.
Results
Specific clinical variables predicted the expression of individual factors. When the inter-relationship of factors is modelled, some previously significant associations are lost. For example, lower MMSE scores predict psychosis, agitation and behavioural dyscontrol factors, but psychosis and mood predict the agitation factor. Taking these associations into account MMSE scores did not predict agitation.
Conclusions
The complexity of the inter-relations between symptoms, factors and clinical variables is efficiently captured by this MIMIC model. | en |
dc.description.sponsorship | We are grateful for funding from the Alzheimer's Research Trust, the MRC Centre for Neurodegeneration Research, the NIHR BRC Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, KCL, the Alzheimer's Society, Stewart Bequest and Ulster Garden Villages. | en |
dc.format.extent | 434-442 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Neurobiology of Aging | en |
dc.relation.ispartofseries | 32 | en |
dc.relation.ispartofseries | 3 | en |
dc.rights | Y | en |
dc.subject | Neuroscience | en |
dc.subject | Alzheimer's disease | en |
dc.subject | Behavioural sub-phenotypes | en |
dc.subject | Structural Equation Modelling | en |
dc.subject | Confirmatory Factor Analysis (CFA) | en |
dc.subject | Multiple Indicators Multiple Causes (MIMIC) model | en |
dc.subject | Differential Item Functioning (DIF) | en |
dc.subject | Neuropsychiatric Inventory (NPI) | en |
dc.subject | Covariates | en |
dc.title | A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD). | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/lawlorba | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mgill | en |
dc.identifier.rssinternalid | 65640 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.neurobiolaging.2009.03.005 | en |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.neurobiolaging.2009.03.005 | en |