dc.contributor.author | Rowan, Michael | en |
dc.contributor.author | Hu, Neng | en |
dc.date.accessioned | 2015-01-05T15:50:05Z | |
dc.date.available | 2015-01-05T15:50:05Z | |
dc.date.issued | 2013 | en |
dc.date.submitted | 2013 | en |
dc.identifier.citation | Qi YJ, Hu NW, Rowan MJ, Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus., Cerebral cortex (New York, N.Y. : 1991), 23, 4, 2013, 932 - 939 | en |
dc.identifier.issn | 1047-3211 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/72879 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Both electrically induced synaptic long-term potentiation (LTP) and long-term depression have been extensively studied as models of the cellular basis of learning and memory mechanisms. Recently, considerable interest has been generated by the possibility that the activity-dependent persistent reversal of previously established synaptic LTP (depotentiation) may play a role in the time- and state-dependent erasure of memory. Here, we examined the requirement for glutamate receptor activation in experience-induced reversal of previously established LTP in the CA1 area of the hippocampus of freely behaving rats. Continuous exploration of non-aversive novelty for ~30 min, which was associated with hippocampal activation as measured by increased theta power in the electroencephalogram, triggered a rapid and persistent reversal of high frequency stimulation-induced LTP both at apical and basal synapses. Blockade of metabotropic glutamate (mGlu) receptors with mGlu5 subtype-selective antagonists, or N-methyl-D-aspartate (NMDA) receptors with GluN2B subunit-selective antagonists, prevented novelty-induced depotentiation. These findings strongly indicate that activation of both mGlu5 receptors and GluN2B-containing NMDA receptors is required for experience-triggered induction of depotentiation at CA3-CA1 synapses. The mechanistic concordance of the present and previous studies of experience-induced and electrically induced synaptic depotentiation helps to integrate our understanding of the neurophysiological underpinnings of learning and memory. | en |
dc.format.extent | 932 | en |
dc.format.extent | 939 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Cerebral cortex (New York, N.Y. : 1991) | en |
dc.relation.ispartofseries | 23 | en |
dc.relation.ispartofseries | 4 | en |
dc.rights | Y | en |
dc.subject | Learning | en |
dc.title | Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mrowan | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hunw | en |
dc.identifier.rssinternalid | 92062 | en |
dc.identifier.doi | http://dx.doi.org/10.1093/cercor/bhs086 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Neuroscience | en |
dc.contributor.sponsor | European Union Framework Programme 7 (FP7) | en |
dc.contributor.sponsorGrantNumber | MEMOLOAD 201159 | en |
dc.contributor.sponsor | Health Research Board (HRB) | en |
dc.contributor.sponsorGrantNumber | COEN/2011/11 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 10/IN.1/B300 | en |