dc.contributor.author | ROWAN, MICHAEL | en |
dc.date.accessioned | 2016-01-07T15:42:58Z | |
dc.date.available | 2016-01-07T15:42:58Z | |
dc.date.created | 2014 | en |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Hu, N.-W. Nicoll, A.J. Zhang, D. Mably, A.J. O'Malley, T. Purro, S.A. Terry, C. Collinge, J. Walsh, D.M. Rowan, M.J., MGlu5 receptors and cellular prion protein mediate amyloid-ß- facilitated synaptic long-term depression in vivo, Nature Communications, 5, 2014 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/75498 | |
dc.description.abstract | NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer's disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively unexplored. Here we describe how Aβ facilitates NMDAR-independent long-term depression of synaptic transmission in the hippocampus in vivo. Synthetic Aβ and Aβ in soluble extracts of Alzheimer's disease brain usurp endogenous acetylcholine muscarinic receptor-dependent long-term depression, to enable long-term depression that required metabotropic glutamate-5 receptors (mGlu5Rs). We also find that mGlu5Rs are essential for Aβ-mediated inhibition of NMDAR-dependent long-term potentiation in vivo. Blocking Aβ binding to cellular prion protein with antibodies prevents the facilitation of long-term depression. Our findings uncover an overarching role for Aβ-PrP(C)-mGlu5R interplay in mediating both LTD facilitation and LTP inhibition, encompassing NMDAR-mediated processes that were previously considered primary. | en |
dc.relation.ispartofseries | Nature Communications | en |
dc.relation.ispartofseries | 5 | en |
dc.rights | Y | en |
dc.subject | NMDA-type glutamate receptors (NMDARs) | en |
dc.title | MGlu5 receptors and cellular prion protein mediate amyloid-ß- facilitated synaptic long-term depression in vivo | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mrowan | en |
dc.identifier.rssinternalid | 101709 | en |
dc.identifier.doi | http://dx.doi.org/10.1038/ncomms4374 | en |
dc.rights.ecaccessrights | openAccess | |
dc.identifier.rssuri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84895804374&partnerID=40&md5=2fa58ddd69080d0e3f16db0f9cb6e0f7 | en |