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Sustained expression of fis, the gene coding for the Fis nucleoid-associated protein, during the stationary phase of growth in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
The Factor for Inversion Stimulation (Fis) is a global regulator of virulence genes in
Salmonella enterica serovar Typhimurium. Previously, the Fis protein was throught to be
expressed only during the early exponential ...
Evolution of the OmpR regulon in Salmonella enterica serovar Typhimurium and Escherichia coli in response to low pH
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Two-component systems (TCS) enable bacteria to sense, respond and adapt to a wide
range of environmental stimuli. The OmpR/EnvZ TCS is composed of the inner
membrane sensor kinase EnvZ and the response regulator OmpR. In ...
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)
The functional brain is critically dependent on a highly specific and perfectly timed
gene-expression programme that underlies neuronal connectivity. Each step of
this process, which includes cell migration, axon guidance, ...
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)
Transcriptional repression is an important part of gene regulation. In the budding
yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to
gene promoters to repress transcription in response to ...
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)
One of the main functions of the brain is to process information from the
environment. All input to the neocortex passes through the thalamus in order to be
handled. Therefore, proper connectivity between the thalamus and ...
Characterisation of the second binding protein of immunoglobulin (SBi) in Straphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)
The second binding protein for immunoglobulin (Sbi) of Staphylococcus aureus
comprises two IgG binding domains (D1 and D2) that share 30% sequence homology
with the IgG binding domains of protein A (Spa) and two domains ...
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
The H-NS protein represses the transcription of hundreds of genes in Gram-negative
bacteria. De-repression is achieved by a multitude of mechanisms, many of which
involve binding of a protein to DNA at the repressed promoter ...
Expression of hns and stpA in Salmonella enterica servoar Typhimurium
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
H-NS-like proteins are widespread amongst Enterobacteriaceae and other Gramnegative bacteria. They are small (15 kDa) nucleoid associated proteins involved in many cellular processes such as replication, transposition, ...
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Staphylococcus aureus is a human pathogen that causes invasive infections.
The ability to internalize into and persist within host cells is thought to contribute to
pathogenesis. The study described here has identified a ...
From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive weakening of limb and bulbar muscles resulting in paralysis and death from
respiratory failure within three to five years ...