Observations of the natural history and long-term outcomes of deep venous thrombosis
Citation:
Ann M. O'Shaughnessy, 'Observations of the natural history and long-term outcomes of deep venous thrombosis', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Anatomy, 2001, pp 129Download Item:
Abstract:
One hundred above knee deep vein thromboses (DVT) from 89 patients (11
bilateral thrombosis) were examined to determine the dynamic status of the
thrombi in the first year and to detennine the long-term clinical outcome at
three years. The patients in the study included patients with a terminal
illness, with a previous history of DVT or with reversible risk factors. The
mortality rate in this study was 14%. The majority of deaths occurred as a
result of an underlying primary disease (e.g. cancer) and 3% died from a
pulmonary embolism (PE). The treatment regime followed was carried out
by a number of referring physicians from different specialities, independent
of any input from the Vascular Laboratory. The initial treatment regime
differed among the patients. Some physicians preferred to treat with the
more established regime of intravenous (IV) heparin and bed rest instead of
the more recent treatment of subcutaneous low molecular weight (SC LMW)
heparin and early mobility. The duration of anticoagulant therapy also varied
with most physicians treating the patient for six months regardless of their
risk factors. A number of symptomatic and asymptomatic events (PE’s,
extension of thrombi, new DVT’s) were recorded in the follow-up period
especially in the initial and late phase. The asymptomatic events were
diagnosed by duplex ultrasound and it is thought that probable additional
asymptomatic events may have occurred but closer time intervals between
duplex ultrasound scanning would be required to document them.
Author: O'Shaughnessy, Ann M.
Advisor:
O'Brien, M.Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of AnatomyNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.iePrint thesis water damaged as a result of the Berkeley Library Podium flood 25/10/2011
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Full text availableKeywords:
Anatomy, Ph.D., Ph.D. Trinity College DublinMetadata
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