Synthesis, biological evaluation and subsequent SAR of four novel families of alkyliphatic twin drugs
Citation:
Jonathan Corcoran, 'Synthesis, biological evaluation and subsequent SAR of four novel families of alkyliphatic twin drugs', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2007, pp 226Download Item:
Abstract:
The I2-IBS is a well known binding site widely distributed in the body of both animals and humans. It is suspected that they are an allosteric binding site of MAO-B. They have also been linked to several conditions such as Alzheimer’s and neuro protection. Their main physiological function appears to be the ability of I2-IBS ligands to attenuate the tolerance to opiod drugs. This link between the I2-IBS and the u-opioid receptor system has made I2-IBS binding sites of pharmalogical importance.
Author: Corcoran, Jonathan
Advisor:
Rozas, IsabelQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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