Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
Citation:
Aedín Minogue, 'Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2005, pp 351Download Item:
Abstract:
Long-term potentiation (LTP) is considered to be a possible neurophysiological
model for learning and memory and consistent with this, is the observation that LTP
is sensitive to stress, injury and insult. This thesis investigates the effects of amyloid-
β (Aβ) and subsequent cellular signalling pathways on expression of LTP in
perforant-path granule cell synapses. Evidence suggests that an age-related
impairment in LTP exists in hippocampus and that upregulation of proinflammatory
signalling may underpin this effect. This observation indicates that
hippocampus may be more susceptible to stress or insult with age. Consequently, the
effects of Aβ administration on LTP in hippocampus of adult and aged rats was
investigated.
Author: Minogue, Aedín
Advisor:
Lynch, MarinaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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