dc.contributor.advisor | Lynch, Marina | |
dc.contributor.author | Minogue, Aedín | |
dc.date.accessioned | 2019-05-01T13:35:48Z | |
dc.date.available | 2019-05-01T13:35:48Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Aedín Minogue, 'Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2005, pp 351 | |
dc.identifier.other | THESIS 7564 | |
dc.identifier.uri | http://hdl.handle.net/2262/86508 | |
dc.description.abstract | Long-term potentiation (LTP) is considered to be a possible neurophysiological
model for learning and memory and consistent with this, is the observation that LTP
is sensitive to stress, injury and insult. This thesis investigates the effects of amyloid-
β (Aβ) and subsequent cellular signalling pathways on expression of LTP in
perforant-path granule cell synapses. Evidence suggests that an age-related
impairment in LTP exists in hippocampus and that upregulation of proinflammatory
signalling may underpin this effect. This observation indicates that
hippocampus may be more susceptible to stress or insult with age. Consequently, the
effects of Aβ administration on LTP in hippocampus of adult and aged rats was
investigated. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12438723 | |
dc.subject | Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 351 | |
dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |