dc.contributor.author | Dev, Kumlesh | |
dc.date.accessioned | 2019-08-20T10:47:07Z | |
dc.date.available | 2019-08-20T10:47:07Z | |
dc.date.issued | 2000 | |
dc.date.submitted | 2000 | en |
dc.identifier.citation | Daw, M.I, Chittajallu, R, Bortolotto, Z.A, Dev, K.K, Duprat, F, Henley, J.M, Collingridge, G.L, Isaac, J.T.R. PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses, Neuron, 2000, 28, 3, 873-886 | en |
dc.identifier.other | Y | |
dc.identifier.uri | doi: 10.1016/S0896-6273(00)00160-4 | |
dc.identifier.uri | http://hdl.handle.net/2262/89240 | |
dc.description | PUBLISHED | en |
dc.description.abstract | We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide (“pep2-SVKI”) into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. Pep2-SVKI, but not a control or PICK1 selective peptide, caused AMPAR-mediated EPSC amplitude to increase in approximately one-third of control neurons and in most neurons following the prior induction of LTD. Pep2-SVKI also blocked LTD; however, this occurred in all neurons. A PKC inhibitor prevented these effects of pep2-SVKI on synaptic transmission and LTD. We propose a model in which the maintenance of LTD involves the binding of AMPARs to PDZ proteins to prevent their reinsertion. We also present evidence that PKC regulates AMPAR reinsertion during dedepression. | en |
dc.format.extent | 873 | en |
dc.format.extent | 886 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Neuron; | |
dc.relation.ispartofseries | 28; | |
dc.rights | Y | en |
dc.subject | Receptors | en |
dc.subject | AMPA | en |
dc.subject | Synapses | en |
dc.subject | Homeostatic synaptic | en |
dc.title | PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/devk | |
dc.identifier.rssinternalid | 57129 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Neuroscience | en |