| dc.contributor.author | Southern, John | en |
| dc.contributor.author | Kelly, Vincent | en |
| dc.contributor.author | Connon, Stephen | en |
| dc.date.accessioned | 2022-02-14T15:47:07Z | |
| dc.date.available | 2022-02-14T15:47:07Z | |
| dc.date.issued | 2020 | en |
| dc.date.submitted | 2020 | en |
| dc.identifier.citation | Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism, Chemical communications, 56, 2020, 3915 - 3918 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | http://hdl.handle.net/2262/98098 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | Eukaryotic tRNA-guanine transglycosylase (TGT) – an enzyme
recently recognised to be of potential therapeutic importance –
catalyses base-exchange of guanine for queuine at the wobble
position of tRNAs associated with 4 amino acids via a distinct
mechanism to that reported for its eubacterial homologue. The
presence of queuine is unequivocally required as a trigger for
reaction between the enzyme and tRNA and exhibits cooperativity
not seen using guanine as a substrate. | en |
| dc.format.extent | 3915 | en |
| dc.format.extent | 3918 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Chemical communications | en |
| dc.relation.ispartofseries | 56 | en |
| dc.rights | Y | en |
| dc.subject | Eukaryotic tRNA-guanine transglycosylase (TGT) | en |
| dc.subject | queuine | en |
| dc.subject | eubacterial homologue | en |
| dc.title | The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/southerj | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/kellyvp | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/connons | en |
| dc.identifier.rssinternalid | 215415 | en |
| dc.identifier.doi | https://doi.org/10.1039/C9CC09887A | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.orcid_id | 0000-0001-8659-5284 | en |
| dc.status.accessible | N | en |
