The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism
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2020Access:
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Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism, Chemical communications, 56, 2020, 3915 - 3918Download Item:
Abstract:
Eukaryotic tRNA-guanine transglycosylase (TGT) – an enzyme
recently recognised to be of potential therapeutic importance –
catalyses base-exchange of guanine for queuine at the wobble
position of tRNAs associated with 4 amino acids via a distinct
mechanism to that reported for its eubacterial homologue. The
presence of queuine is unequivocally required as a trigger for
reaction between the enzyme and tRNA and exhibits cooperativity
not seen using guanine as a substrate.
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http://people.tcd.ie/southerjhttp://people.tcd.ie/kellyvp
http://people.tcd.ie/connons
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Chemical communications56
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https://doi.org/10.1039/C9CC09887AMetadata
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