Browsing by Author "Connon, Stephen"
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Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
Connon, Stephen; Reynolds, John; Lynam-Lennon, Niamh; Phelan, James; Maher, Stephen (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched ?-lactams
Connon, Stephen (2022)An unprecedented organocatalytic process involving the asymmetric addition of azide to meso-anhydrides has been developed, promoted by novel sulfamide-substituted Cinchona alkaloid-based catalysts. Readily available glutaric ... -
Conformational control of nonplanar free base porphyrins: Towards bifunctional catalysts of tunable basicity
Senge, Mathias; Connon, Stephen (2018) -
De-novo designed ??-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P
Kelly, Vincent; Southern, John; Connon, Stephen (2022)An investigation into the effect of modified β-lysines on the growth rates of eubacterial cells is reported. It is shown that the effects observed are due to the post translational modification of Elongation Factor P (EFP) ... -
Enantioselective Alkylation of 2-Oxindoles Catalyzed by a Bifunctional Phase-Transfer Catalyst: Synthesis of (− )-Debromoflustramine B
Connon, Stephen (2018)A new bifunctional phase-transfer catalyst that employs hydrogen bonding as a control element was developed to promote efficient enantioselective SN2 reactions for the construction all-carbon quaternary stereocenters in ... -
The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism
Southern, John; Kelly, Vincent; Connon, Stephen (2020)Eukaryotic tRNA-guanine transglycosylase (TGT) – an enzyme recently recognised to be of potential therapeutic importance – catalyses base-exchange of guanine for queuine at the wobble position of tRNAs associated with ... -
The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity.
Kelly, Vincent; Senge, Mathias; Southern, John; Hokamp, Karsten; Connon, Stephen (2021)Base-modification can occur throughout a transfer RNA molecule; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. ...