Enantioselective Alkylation of 2-Oxindoles Catalyzed by a Bifunctional Phase-Transfer Catalyst: Synthesis of (− )-Debromoflustramine B
Citation:
Craig, R. and Sorrentino, E. and Connon, S.J., Enantioselective Alkylation of 2-Oxindoles Catalyzed by a Bifunctional Phase-Transfer Catalyst: Synthesis of (â )-Debromoflustramine B, Chemistry - A European Journal, 24, 18, 2018, 4528-4531Abstract:
A new bifunctional phase-transfer catalyst that employs hydrogen bonding as a control element was developed to promote efficient enantioselective SN2 reactions for the construction all-carbon quaternary stereocenters in high yield and excellent enantioselectivity (up to 97 % ee) utilizing the alkylation of a malleable oxindole substrate. The utility of the methodology was demonstrated through a concise and highly enantioselective synthesis of (−)-debromoflustramine B.
Author's Homepage:
http://people.tcd.ie/connons
Author: Connon, Stephen
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Journal ArticleCollections
Series/Report no:
Chemistry - A European Journal;24;
18;
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Full text availableKeywords:
debromoflustramine B, Phase-transfer, EnantioselectivityDOI:
http://dx.doi.org/10.1002/chem.201800313Metadata
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