Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 503-522 of 638
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The relationship between syncope, depression and anti-depressant use in older adults
(2014)The authors aim to examine the rates of depression in older patients reporting syncope and the effect of anti–depressants (ADs) on the rates of syncope. This study demonstrates an increased risk of syncope in patients with ... -
Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
(BioMed Central, 2008)Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM). Vitamin D3 insufficiency ... -
Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
(2014)Background: Neural tube defects (NTDs), which are among the most common congenital malformations, are influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor, making ... -
Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
(2016)Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in ... -
Respiratory measures in amyotrophic lateral sclerosis
(2018)Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with respiration. Death often results from respiratory failure within ... -
Response: Disseminated tuberculosis.
(Oxford University Press, 2017)Lymphopaenia is described among patients with tuberculosis.The lymphocyte count for the patient in our publication prior to treatment was 0.8 (1–2 1016ml). At the time of writing, he is still receiving his anti-tuberculous ... -
Retrospective analysis of attitudes to ageing in the Economist: apocalyptic demography for opinion formers.
(2009)Objective To investigate the description of older people and ageing in a major weekly newspaper, influential in political and financial circles, to see whether it reflected ageing in a balanced manner, and to what extent ... -
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.
(2006)Background? Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate ... -
Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine
(2014)Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase red uctase (MTRR), riboflavin- dependent enzymes, participat e in homocysteine metabolism. Reported effects of riboflavin status on the ... -
Risk management framework for nano-biomaterials used in medical devices and advanced therapy medicinal products
(2020)The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
(2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
The role of chemokines in acute and chronic hepatitis C infection.
(2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
(2016)The Notch signaling pathway is conserved from Droso- phila to mammals and is critically involved in develop- mental processes. In the immune system, it has been established that Notch signaling regulates multiple steps ... -
RSOS submission raw data
(RSOS, 2017)