Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 580-599 of 638
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T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
(Elsevier, 2007)Autophagy is a recently recognized immune effect or mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies.
(2016)Abstract: The main objective of this study was to optimize and characterize a drug delivery carrier for doxorubicin, intended to be intravenously administered, capable of improving the therapeutic index of the chemotherapeutic ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
(2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ... -
Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features ... -
TB osteomyelitis
(Oxford University Press, 2016)Osteoarticular TB is very rare and as such, physicians are less experienced in diagnosing osteoarticular TB. This is compounded by the fact that the diagnosis of osteoarticular TB is difficult to achieve. Therefore, awareness ... -
Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.
(2010)BACKGROUND Suggestive, but not conclusive, studies implicate many genetic variants in oral cleft etiology. We used a large, ethnically homogenous study population to test whether reported associations between nonsyndromic ... -
Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis.
(2006)The therapeutic options for anti-neutrophil cytoplasm antibody (ANCA)-associated systemic vasculitis (AASV) remain limited and hampered by adverse effects. One potential novel therapeutic avenue involves inhibition of ... -
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
(1999)Recent reports have implicated the "thermolabile" (T) variant of methylenetetrahydrofolate reductase (MTHFR) in the causation of folate-dependent neural tube defects (NTDs). We report herein the largest genetic study of ... -
A time transect of exomes from a Native American population before and after European contact
(2016)A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this ... -
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
(2018)The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate ... -
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
(2013)BACKGROUND: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier ... -
A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis
(PLoS, 2011)Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, we provide evidence for ... -
TNXB mutations can cause vesicoureteral reflux.
(2013)Primary vesicoureteral reflux (VUR) is the most common congenital anomaly of the kidney and the urinary tract, and it is a major risk factor for pyelonephritic scarring and CKD in children. Although twin studies support ... -
ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients
(2019)Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third leading cause of death worldwide. Recent reports have indicated that dysfunctional iron handling in the lungs of COPD ... -
Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ?? T Cells.
(2013)Expression of the orphan receptor Toll IL-1R8/single Ig IL-1–related receptor has been reported to be reduced in the peripheral blood of psoriatic arthritis patients. However whether TIR8/SIGIRR activity plays a specific ... -
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
(2020)Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. ... -
TORCing up the importance of calcium signaling.
(2011-08)